Summary

Name NKX2-5
Full Name Homeobox protein Nkx-2.5
Synonyms Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E | CSX, NKX2.5, NKX2E
Primary ID P52952
Links - -
Type protein
Relations 10
Function Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation NKX2-5 0.337
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png binding NKX2-5 0.469
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNNB1 0.356
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TBX5 0.801
Publications: 1
+ img/unknown.png transcriptional regulation NPPB 0.337
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ANKRD1 0.346
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MEF2C 0.731
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GATA4 0.845
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LYL1 0.321
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYL2 0.606
Publications: 1 Organism: Rattus Norvegicus