Summary

Name TEAD4
Full Name Transcriptional enhancer factor TEF-3
Synonyms TEA domain family member 4, TEAD-4, Transcription factor 13-like 1, Transcription factor RTEF-1 | RTEF1, TCF13L1, TEF3
Primary ID Q15561
Links - -
Type protein
Relations 2
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding TEAD4 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TEAD4 0.52
Publications: 1 Organism: Homo Sapiens