Name	TEAD4
Full Name	Transcriptional enhancer factor TEF-3
Synonyms	TEA domain family member 4, TEAD-4, Transcription factor 13-like 1, Transcription factor RTEF-1 \| RTEF1, TCF13L1, TEF3
Primary ID	Q15561
Links	- -
Type	protein
Relations	4
Pathways	myCAF signaling in PDAC
Function	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.