3.0
Summary
| Name |  MED1View Modifications |
| Full Name | Mediator of RNA polymerase II transcription subunit 1 |
| Synonyms | Activator-recruited cofactor 205 kDa component, ARC205, Mediator complex subunit 1, Peroxisome proliferator-activated receptor-binding protein, PBP, PPAR-binding protein, Thyroid hormone receptor-associated protein complex 220 kDa component, Trap220, Thyroid receptor-interacting protein 2, TR-interacting protein 2, TRIP-2, Vitamin D receptor-interacting protein complex component DRIP205, p53 regulatory protein RB18A | ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2 |
| Primary ID | Q15648 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK3 | up-regulates 
phosphorylation
|
MED1 | 0.267 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates
phosphorylation
|
MED1 | 0.362 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | Gbeta | up-regulates
phosphorylation
|
MED1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | up-regulates
phosphorylation
|
MED1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MED1 | form complex 
binding
|
Core mediator complex | 0.803 |
| Publications: | 1 | Organism: | Homo Sapiens | |