Relation Results

Summary

Name ELAVL1
Full Name ELAV-like protein 1
Synonyms Hu-antigen R, HuR | HUR
Primary ID Q15717
Links - -
Type protein
Relations 11
Function RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involv ...
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Type: Score: Layout: SPV 
0.5610.6280.3260.5320.20.3510.307CHEK2ELAVL1PRKCDCHUKMAPK14ADAM10MAPK15MAPKAPK2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CHEK2up-regulates activity img/direct-activation.png phosphorylation ELAVL1 0.561
Identifier Residue Sequence Organism Cell Line
SIGNOR-278161 Ser100 VSYARPSsEVIKDAN Homo sapiens
pmid sentence
Taken together, these findings indicate that phosphorylation at residue S100 by Chk2 enhances HuR-binding to the occludin mRNA, while phosphorylation at S88 and T118 reduces this interaction; these modifications in turn regulate occludin translation.
Publications: 1 Organism: Homo Sapiens
+ PRKCDup-regulates img/direct-activation.png phosphorylation ELAVL1 0.628
Identifier Residue Sequence Organism Cell Line
SIGNOR-163524 Ser221 QAQRFRFsPMGVDHM Homo sapiens
pmid sentence
Tandem phosphorylation of serines 221 and 318 by protein kinase cdelta coordinates mrna binding and nucleocytoplasmic shuttling of hurstabilization of mrna by the ubiquitous rna binding protein human antigen r (hur), a member of the embryonic lethal abnormal vision (elav) protein family, requires canonical binding to au-rich element (are)-bearing target mrna and export of nuclear hur-mrna complexes to the cytoplasm. In human mesangial cells (hmc) both processes are induced by angiotensin ii (angii) via protein kinase cdelta (pkcdelta)-triggered serine phosphorylation of hur.
Identifier Residue Sequence Organism Cell Line
SIGNOR-163528 Ser318 GDKILQVsFKTNKSH Homo sapiens
pmid sentence
Tandem phosphorylation of serines 221 and 318 by protein kinase cdelta coordinates mrna binding and nucleocytoplasmic shuttling of hurstabilization of mrna by the ubiquitous rna binding protein human antigen r (hur), a member of the embryonic lethal abnormal vision (elav) protein family, requires canonical binding to au-rich element (are)-bearing target mrna and export of nuclear hur-mrna complexes to the cytoplasm. In human mesangial cells (hmc) both processes are induced by angiotensin ii (angii) via protein kinase cdelta (pkcdelta)-triggered serine phosphorylation of hur.
Publications: 2 Organism: Homo Sapiens
+ CHUKdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ELAVL1 0.326
Identifier Residue Sequence Organism Cell Line
SIGNOR-276422 Ser304 EAAMAIAsLNGYRLG Homo sapiens LNCaP Cell
pmid sentence
Furthermore, mutational analysis indicates that IKKα-dependent phosphorylation at Ser-304 is crucial to the binding of HuR to β-TrCP1. Mechanistically, this HuR degradation pathway differs from that reported for heat shock and hypoxia, which underlies the complexity in the regulation of HuR turnover under different stress stimuli. 
Publications: 1 Organism: Homo Sapiens
+ CHEK2down-regulates activity img/direct_inhibition.png phosphorylation ELAVL1 0.561
Identifier Residue Sequence Organism Cell Line
SIGNOR-278163 Ser88 LNGLRLQsKTIKVSY Homo sapiens
pmid sentence
Given the fact that Chk2 phosphorylates HuR at residues S88, S100 and T118 and that each individual phosphorylation site by Chk2 plays a distinct role in regulating HuR- binding to different target mRNAs (22,42), we further tested HuR mutants with alanine substitutions at each of the Chk2 phosphorylation sites.
Identifier Residue Sequence Organism Cell Line
SIGNOR-278162 Thr118 SGLPRTMtQKDVEDM Homo sapiens
pmid sentence
Given the fact that Chk2 phosphorylates HuR at residues S88, S100 and T118 and that each individual phosphorylation site by Chk2 plays a distinct role in regulating HuR- binding to different target mRNAs, we further tested HuR mutants with alanine substitutions at each of the Chk2 phosphorylation sites.
Publications: 2 Organism: Homo Sapiens
+ MAPK14up-regulates img/direct-activation.png phosphorylation ELAVL1 0.532
Identifier Residue Sequence Organism Cell Line
SIGNOR-186135 Thr118 SGLPRTMtQKDVEDM Homo sapiens
pmid sentence
P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna.
Identifier Residue Sequence Organism Cell Line
SIGNOR-186138 Homo sapiens
pmid sentence
P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna.
Publications: 2 Organism: Homo Sapiens
+ ELAVL1up-regulates quantity img/direct-activation.png post transcriptional regulation ADAM10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266862 Homo sapiens
pmid sentence
Neuronal ELAV (nELAV) proteins are RNA-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as Alzheimer's disease (AD). The experiments show for the first time that ADAM10mRNA represents a nELAV target and that these RNA-binding proteins can play a role in the post-transcriptional regulation of ADAM10 expression. nELAV proteins specifically bind the ADAM10 mRNA and this binding is disrupted following Aβ exposure
Publications: 1 Organism: Homo Sapiens
+ MAPK15down-regulates activity img/direct_inhibition.png phosphorylation ELAVL1 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-278314 Homo sapiens
pmid sentence
ERK8 phosphorylates HuR to prevent its binding to PDCD4 mRNA A. ERK8 or control siRNA was transfected into HeLa cells for 48 h followed by treatment of cells with 0.5 mM H2O2 or PBS for 1 h. Cells were fixed and immunofluorescence was performed to monitor HuR localization.
Publications: 1 Organism: Homo Sapiens
+ MAPKAPK2up-regulates img/direct-activation.png phosphorylation ELAVL1 0.307
Identifier Residue Sequence Organism Cell Line
SIGNOR-166622 Homo sapiens
pmid sentence
Mk2 and mk3 participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating the are-binding proteins ttp and hur, and by regulating eef2k
Publications: 1 Organism: Homo Sapiens
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