| + |
CHEK2 | up-regulates activity 
phosphorylation
|
ELAVL1 |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278161 |
Ser100 |
VSYARPSsEVIKDAN |
Homo sapiens |
|
| pmid |
sentence |
| 21745814 |
Taken together, these findings indicate that phosphorylation at residue S100 by Chk2 enhances HuR-binding to the occludin mRNA, while phosphorylation at S88 and T118 reduces this interaction; these modifications in turn regulate occludin translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCD | up-regulates
phosphorylation
|
ELAVL1 |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163524 |
Ser221 |
QAQRFRFsPMGVDHM |
Homo sapiens |
|
| pmid |
sentence |
| 20086103 |
Tandem phosphorylation of serines 221 and 318 by protein kinase cdelta coordinates mrna binding and nucleocytoplasmic shuttling of hurstabilization of mrna by the ubiquitous rna binding protein human antigen r (hur), a member of the embryonic lethal abnormal vision (elav) protein family, requires canonical binding to au-rich element (are)-bearing target mrna and export of nuclear hur-mrna complexes to the cytoplasm. In human mesangial cells (hmc) both processes are induced by angiotensin ii (angii) via protein kinase cdelta (pkcdelta)-triggered serine phosphorylation of hur. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163528 |
Ser318 |
GDKILQVsFKTNKSH |
Homo sapiens |
|
| pmid |
sentence |
| 20086103 |
Tandem phosphorylation of serines 221 and 318 by protein kinase cdelta coordinates mrna binding and nucleocytoplasmic shuttling of hurstabilization of mrna by the ubiquitous rna binding protein human antigen r (hur), a member of the embryonic lethal abnormal vision (elav) protein family, requires canonical binding to au-rich element (are)-bearing target mrna and export of nuclear hur-mrna complexes to the cytoplasm. In human mesangial cells (hmc) both processes are induced by angiotensin ii (angii) via protein kinase cdelta (pkcdelta)-triggered serine phosphorylation of hur. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHUK | down-regulates quantity by destabilization 
phosphorylation
|
ELAVL1 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276422 |
Ser304 |
EAAMAIAsLNGYRLG |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 23115237 |
Furthermore, mutational analysis indicates that IKKα-dependent phosphorylation at Ser-304 is crucial to the binding of HuR to β-TrCP1. Mechanistically, this HuR degradation pathway differs from that reported for heat shock and hypoxia, which underlies the complexity in the regulation of HuR turnover under different stress stimuli. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHEK2 | down-regulates activity
phosphorylation
|
ELAVL1 |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278163 |
Ser88 |
LNGLRLQsKTIKVSY |
Homo sapiens |
|
| pmid |
sentence |
| 21745814 |
Given the fact that Chk2 phosphorylates HuR at residues S88, S100 and T118 and that each individual phosphorylation site by Chk2 plays a distinct role in regulating HuR- binding to different target mRNAs (22,42), we further tested HuR mutants with alanine substitutions at each of the Chk2 phosphorylation sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278162 |
Thr118 |
SGLPRTMtQKDVEDM |
Homo sapiens |
|
| pmid |
sentence |
| 21745814 |
Given the fact that Chk2 phosphorylates HuR at residues S88, S100 and T118 and that each individual phosphorylation site by Chk2 plays a distinct role in regulating HuR- binding to different target mRNAs, we further tested HuR mutants with alanine substitutions at each of the Chk2 phosphorylation sites. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
ELAVL1 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186135 |
Thr118 |
SGLPRTMtQKDVEDM |
Homo sapiens |
|
| pmid |
sentence |
| 19528229 |
P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19528229 |
P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPKAPK2 | up-regulates
phosphorylation
|
ELAVL1 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166622 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Mk2 and mk3 participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating the are-binding proteins ttp and hur, and by regulating eef2k |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELAVL1 | up-regulates quantity
post transcriptional regulation
|
ADAM10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19221430 |
Neuronal ELAV (nELAV) proteins are RNA-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as Alzheimer's disease (AD). The experiments show for the first time that ADAM10mRNA represents a nELAV target and that these RNA-binding proteins can play a role in the post-transcriptional regulation of ADAM10 expression. nELAV proteins specifically bind the ADAM10 mRNA and this binding is disrupted following Aβ exposure |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK15 | down-regulates activity
phosphorylation
|
ELAVL1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278314 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26595526 |
ERK8 phosphorylates HuR to prevent its binding to PDCD4 mRNA A. ERK8 or control siRNA was transfected into HeLa cells for 48 h followed by treatment of cells with 0.5 mM H2O2 or PBS for 1 h. Cells were fixed and immunofluorescence was performed to monitor HuR localization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ELAVL1
- 
- 