| + |
CDK2 | up-regulates
phosphorylation
|
CCDC6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121198 |
Ser244 |
QPVSAPPsPRDISME |
Homo sapiens |
|
| pmid |
sentence |
| 14712216 |
Serine 244 phosphorylation is required for h4 apoptotic function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates activity
phosphorylation
|
CCDC6 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276003 |
Ser244 |
QPVSAPPsPRDISME |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14712216 |
We have characterized the H4(D10S170) gene product, showing that it is a ubiquitously expressed 55 KDa nuclear and cytosolic protein that is phosphorylated following serum stimulation. This phosphorylation was found to depend on mitogen-activated protein kinase (MAPK) Erk1/2 activity and to be associated to the relocation of H4(D10S170) from the nucleus to the cytosol. S244 is the major target residue of ERK1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates
phosphorylation
|
CCDC6 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199276 |
Thr434 |
TPPPSPNtQTPVQPP |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 23108047 |
Phosphorylation of ccdc6 at thr434 by atm during dna damage response prevents fbxw7-mediated ccdc6 degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW7 | down-regulates
binding
|
CCDC6 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199279 |
|
|
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 23108047 |
Fbxw7 interacts with and targets ccdc6 for ubiquitin-mediated proteasomal degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |