| + |
SOSTDC1 | down-regulates activity 
|
BMP4 |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242749 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18032587 |
SOSTDC1 is orthologous to a recently characterized murine antagonist of BMPs-2, -4, and -7 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BMP4 | up-regulates 
binding
|
BMP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11178121 |
Bmps are dimeric proteins with a single inter-chain disulfide bond. The dimeric conformation is anabsolute requirement for the biological action and interaction with receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
YAP1 | up-regulates quantity by expression 
transcriptional regulation
|
BMP4 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199066 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
In our analysis bmp4 (bone morphogenetic protein 4) and fstl3 (follistatin-related protein 3) increased their expression in response to hyap1 s127a overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
EXT1 | up-regulates activity
|
BMP4 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264018 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24860992 |
Decreased Ext1 was shown to reduce the level of Wnt8 and BMP4 signaling and disrupt ventral-specific gene expression. Ext1 function is required for maintenance of normal levels of BMP and wnt, as well as their target genes. In addition, expression of xbra and the establishment of ventral mesoderm depend upon normal levels of Ext1. These findings suggest that ext1-dependent synthesis of HSPG is critical for wnt and BMP signaling, mesodermal identity, and ventral pattern. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP4 | up-regulates
binding
|
BMPR1A/1B/2 |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7673243 |
We have isolated a cdna encoding a novel transmembrane serine/threonine kinase from human skin fibroblasts which we demonstrate here to be a type ii receptor that binds bmp-4. This receptor (brk-3) is distantly related to other known type ii receptors and is distinguished from them by an extremely long carboxyl-terminal sequence following the intracellular kinase domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | Adipogenesis |
| + |
NFKB1 | down-regulates quantity by repression 
transcriptional regulation
|
BMP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266086 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17350185 |
The effect of TNF-alpha on the Bmp4 promoter is mediated through NF-kB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP4 | up-regulates
binding
|
BMPR1A |
0.887 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253548 |
|
|
|
|
| pmid |
sentence |
| 26330344 |
BMP interacts with specific receptors on the cell surface, BMP receptor types 1 and 2 (BMPr1 and BMPr2). |
|
| Publications: |
1 |
| + |
SMAD1/4 | up-regulates quantity by expression
transcriptional regulation
|
BMP4 |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248842 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 19896409 |
BMPs first bind to and activate their transmembrane serine/threonine kinase receptors, which in turn phosphorylate the transcription factors Smad1/5/8 at its two C-terminal serines (SVS). Phosphorylated Smad1Cter binds to Smad4 (co-Smad) and translocates and accumulates in the nucleus, activating BMP-responsive genes (Fig. 2) [21] and [22], such as BMP4/7 and others. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
RELA | down-regulates quantity by repression
transcriptional regulation
|
BMP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266087 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17350185 |
Co-transfection with pCMV4-RelA alone or in combination with pCMV4p50 repressed pSLA4.1 EX-Lux activity by approximately 75 percent in both H441 and A549 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP4 | up-regulates activity
binding
|
BMPR1A/1B/2 |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235376 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 11282024 |
Bmp-4 and gdf-5 are known to bind to activin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8006002 |
BMP-4 bound to ALK-3 and ALK-6 efficiently |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
TNF | down-regulates quantity by repression
transcriptional regulation
|
BMP4 |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266085 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17350185 |
TNF-alpha represses the activity of a human Bmp4 promoter-luciferase construct, transfected into A549 and H441 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP4 | up-regulates
binding
|
BMPR2 |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-35763 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8006002 |
Bmp-4 bound to alk-3 and alk-6 efficiently |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-30697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7673243 |
We have isolated a cdna encoding a novel transmembrane serine/threonine kinase from human skin fibroblasts which we demonstrate here to be a type ii receptor that binds bmp-4. This receptor (brk-3) is distantly related to other known type ii receptors and is distinguished from them by an extremely long carboxyl-terminal sequence following the intracellular kinase domain. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TEAD1 | up-regulates quantity by expression
transcriptional regulation
|
BMP4 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23673366 |
Taz induces bmp4 transcription through the tead family of transcription factors, which mediate bmp4 promoter activation through binding to tead response element 1 (tre1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP4 | up-regulates
|
MRTFA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21673106 |
These results demonstrate that mrtf-a is essential for the bmp4-mediated induction of pri-mir-143/145 and mature mir-143/145, whereas tgf- -mediated induction of mir-143/145 requires myocd. Mrtf-a is primarily localized in the cytoplasm in unstimulated cells;upon stimulation with bmp4, mrtf-a translocates into the nucleus to promote changes in gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOG | down-regulates
binding
|
BMP4 |
0.809 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100660 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12700180 |
Noggin acts by binding bmps, thus preventing them from binding to their receptors (180). Noggin binds with various degrees of affinity bmp-2, -4, -5, -6, and -7, gdf-5, gdf-6, and vg1, but not other members of the tgf- family of peptides |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU5F1 | down-regulates quantity by repression
transcriptional regulation
|
BMP4 |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254932 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 17068183 |
To enhance our understanding of the molecular basis of this differentiation event in humans, we used a functional genomics approach involving RNA interference-mediated suppression of OCT4 function in a human ESC line and analysis of the resulting transcriptional profiles to identify OCT4-dependent genes in human cells. We detected altered expression of >1,000 genes, including targets regulated directly by OCT4 either positively (NANOG, SOX2, REX1, LEFTB, LEFTA/EBAF DPPA4, THY1, and TDGF1) or negatively (CDX2, EOMES, BMP4, TBX18, Brachyury [T], DKK1, HLX1, GATA6, ID2, and DLX5), as well as targets for the OCT4-associated stem cell regulators SOX2 and NANOG. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BMP4
- 
- 