Relation Results

Summary

Name WNT8A
Full Name Protein Wnt-8a
Synonyms Protein Wnt-8d | WNT8D
Primary ID Q9H1J5
Links - -
Type protein
Relations 6
Function Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.

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Type: Score: Layout: SPV 
0.630.4890.20.6170.5560.375WNT8ALRP5FRZBEXT1FZD3WIF1SOSTDC1

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Relations
Regulator
Mechanism
target
score ℹ
+ WNT8Aup-regulates img/direct-activation.png binding LRP5 0.63
Identifier Residue Sequence Organism Cell Line
SIGNOR-131987 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
+ FRZBdown-regulates img/direct_inhibition.png binding WNT8A 0.489
Identifier Residue Sequence Organism Cell Line
SIGNOR-51798 Homo sapiens
pmid sentence
We and others demonstrated that fzb-1 blocks wnt-1 and xwnt-8 signaling in xenopus embryos,
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ EXT1up-regulates activity img/indirect-activation.png WNT8A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264019 Homo sapiens
pmid sentence
Decreased Ext1 was shown to reduce the level of Wnt8 and BMP4 signaling and disrupt ventral-specific gene expression. Ext1 function is required for maintenance of normal levels of BMP and wnt, as well as their target genes. In addition, expression of xbra and the establishment of ventral mesoderm depend upon normal levels of Ext1. These findings suggest that ext1-dependent synthesis of HSPG is critical for wnt and BMP signaling, mesodermal identity, and ventral pattern.
Publications: 1 Organism: Homo Sapiens
+ WNT8Aup-regulates img/direct-activation.png binding FZD3 0.617
Identifier Residue Sequence Organism Cell Line
SIGNOR-131984 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
+ WIF1down-regulates img/direct_inhibition.png binding WNT8A 0.556
Identifier Residue Sequence Organism Cell Line
SIGNOR-66892 Homo sapiens
pmid sentence
Here we describe wnt-inhibitory factor-1 (wif-1), a secreted protein that binds to wnt proteins and inhibits their activities.
Publications: 1 Organism: Homo Sapiens
+ SOSTDC1down-regulates activity img/indirect_inhibition.png WNT8A 0.375
Identifier Residue Sequence Organism Cell Line
SIGNOR-242742 Homo sapiens MDA-MB-231 Cell
pmid sentence
For example, SOSTDC1 decreases Wnt signaling by impeding the binding of Wnt8 to the LRP6 receptor
Publications: 1 Organism: Homo Sapiens
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