| + |
DUSP5 | down-regulates 
dephosphorylation
|
MAPK1 |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67355 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10224087 |
Extracellular regulated kinases (erk) 1 and erk2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase vhr. A novel role in down-regulating the erk pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15713638 |
Here we demonstrate that dusp5, an inducible nuclear phosphatase, interacts specifically with erk2 via a kinase interaction motif (kim) within its amino-terminal noncatalytic domain. This binding determines the substrate specificity of dusp5 in vivo, as it inactivates erk2 but not jun n-terminal protein kinase or p38 map kinase. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DUSP5 | down-regulates
dephosphorylation
|
Gbeta |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269912 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10224087 |
Extracellular regulated kinases (erk) 1 and erk2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase vhr. A novel role in down-regulating the erk pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP5 | down-regulates
dephosphorylation
|
MAPK14 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
The activity of mapks can be also regulated by a family of dusps, which dephosphorylates bot phosphotyrosine and phopsphothreonine residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP5 | down-regulates
dephosphorylation
|
ERK1/2 |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10224087 |
Extracellular regulated kinases (erk) 1 and erk2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase vhr. A novel role in down-regulating the erk pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP5 | down-regulates
dephosphorylation
|
MAPK3 |
0.751 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10224087 |
Extracellular regulated kinases (erk) 1 and erk2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase vhr. A novel role in down-regulating the erk pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DUSP5
- 
- 