Summary

Name DUSP7
Full Name Dual specificity protein phosphatase 7
Synonyms Dual specificity protein phosphatase PYST2 | PYST2
Primary ID Q16829
Links - -
Type protein
Relations 4
Function Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ DUSP7down-regulates activity img/direct_inhibition.png dephosphorylation GHR 0.318
Publications: 1 Organism: Cricetulus Griseus
+ DUSP7down-regulates img/direct_inhibition.png dephosphorylation GHR 0.318
Publications: 1 Organism: Homo Sapiens
+ DUSP7down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.654
Publications: 1 Organism: Homo Sapiens
+ DUSP7down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.788
Publications: 1 Organism: Homo Sapiens
Tissue: Skin