Relation Results

Summary

Name TRIM71
Full Name E3 ubiquitin-protein ligase TRIM71
Synonyms Protein lin-41 homolog, RING-type E3 ubiquitin transferase TRIM71, Tripartite motif-containing protein 71 | LIN41
Primary ID Q2Q1W2
Links - -
Type protein
Relations 6
Function E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Pro ...
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Type: Score: Layout: SPV 
0.20.5320.2860.20.2740.296PRKACATRIM71LIN28BSOX17/POU5F1Ub:E2TP53SOX2/POU5F1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKACAup-regulates quantity by stabilization img/direct-activation.png phosphorylation TRIM71 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277454 Ser3 sFPETDFQ in vitro
pmid sentence
 These observations suggested that LINK-A expression potentially inhibits PKA phosphorylation/activity and PKA-mediated phosphorylation of TRIM71 at Ser3.
Publications: 1 Organism: In Vitro
+ TRIM71down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination LIN28B 0.532
Identifier Residue Sequence Organism Cell Line
SIGNOR-272054 Homo sapiens HuH-7 Cell
pmid sentence
In cells, TRIM71 negatively regulates Lin28B protein stability by catalyzing polyubiquitination. 
Publications: 1 Organism: Homo Sapiens
+ SOX17/POU5F1up-regulates quantity by expression img/direct-activation.png transcriptional regulation TRIM71 0.286
Identifier Residue Sequence Organism Cell Line
SIGNOR-269247
pmid sentence
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6).
Publications: 1
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRIM71 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271014 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ TRIM71down-regulates quantity img/direct_inhibition.png ubiquitination TP53 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-278679 Homo sapiens
pmid sentence
LIN41 promotes ubiquitination of p53 in response to RA.|Loss of LIN41 elevates p53 steady-state levels and reduces p53 ubiquitination.
Publications: 1 Organism: Homo Sapiens
+ SOX2/POU5F1up-regulates quantity by expression img/direct-activation.png transcriptional regulation TRIM71 0.296
Identifier Residue Sequence Organism Cell Line
SIGNOR-269239
pmid sentence
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6).
Publications: 1
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