| + |
MEST | down-regulates 
transcriptional regulation
|
CTNNB1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258982 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24827625 |
Our data demonstrate that Mest alleviated CCl4-induced collagen deposition in liver tissue and improved the condition of the liver in rats. Mest also significantly reduced the expression and distribution of β-catenin, α-SMA and Smad3 both in vivo and in vitro, in addition to the viability of HSCs in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | up-regulates quantity by expression 
transcriptional regulation
|
MEST |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255823 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 26893351 |
We found that SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARγ, C/EBPα and MEST. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEST | down-regulates activity
|
LRP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255826 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21375506 |
Mest/Peg1 inhibited maturation of LRP6 by controlling the glycosylation of LRP6. Knockdown of Mest/Peg1, which might enhance Wnt signalling, blocked adipogenic differentiation of 3T3-L1 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MEST
- 
- 