| + |
UBE2I | down-regulates activity 
sumoylation
|
SOX6 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256129 |
Lys404 |
VSPTGIkNEKRGTS |
Homo sapiens |
|
| pmid |
sentence |
| 16442531 |
We show that SOX6 is modified in vitro and in vivo by small ubiquitin‐related modifier (SUMO) on two distinct sites. Mutation of both sites abolished SOX6 sumoylation and increased SOX6 transcriptional activity. SUMO dependent repression of SOX6 transcription was promoted by UBC9 whereas siRNA to UBC9, cotransfection of inactive UBC9 or a SUMO protease increased SOX6 transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256130 |
Lys417 |
TSPVTQkVkDEAAAQP |
Homo sapiens |
|
| pmid |
sentence |
| 16442531 |
We show that SOX6 is modified in vitro and in vivo by small ubiquitin‐related modifier (SUMO) on two distinct sites. Mutation of both sites abolished SOX6 sumoylation and increased SOX6 transcriptional activity. SUMO dependent repression of SOX6 transcription was promoted by UBC9 whereas siRNA to UBC9, cotransfection of inactive UBC9 or a SUMO protease increased SOX6 transcriptional activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SOX6 | up-regulates quantity by expression 
transcriptional regulation
|
CEBPA |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255824 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26893351 |
We found that SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARγ, C/EBPα and MEST |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CENPK | up-regulates activity
binding
|
SOX6 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221820 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 10996314 |
Here we report the cloning of a novel cDNA, termed Solt, from a mouse testis cDNA library. Its gene product, Solt, interacts with the leucine zipper region of SoxLZ/Sox6. In transient transfection assays with SoxLZ/Sox6 containing the transactivation domain of herpes simplex virus VP16, the expression of a luciferase reporter gene under the control of a promoter containing a synthetic cis element that is bound by the HMG box of SoxLZ/Sox6 was poorly enhanced in the presence of Solt. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SOX6 | down-regulates quantity by destabilization
binding
|
CTNNB1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255825 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 26893351 |
In adipocytes, in addition to the direct regulation of PPARγ andC/EBP expression, we showed that SOX6 inhibitsWNT signaling by binding to β-catenin, potentially leading to its degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | down-regulates quantity by repression 
transcriptional regulation
|
HBG2 |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251808 |
|
|
Homo sapiens |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 20395365 |
BCL11A and SOX6 co-occupy the human beta-globin cluster along with GATA1, and cooperate in silencing gamma-globin transcription in adult human erythroid progenitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | down-regulates activity
binding
|
CTNNB1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256073 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 26893351 |
SOX6 interacts with β-catenin in adipocytes, suggesting an inhibition of WNT/β-catenin signaling, thereby promoting adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOX6 | up-regulates quantity by expression 
transcriptional regulation
|
MEST |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255823 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 26893351 |
We found that SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARγ, C/EBPα and MEST. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255822 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 26893351 |
We found that SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARγ, C/EBPα and MEST |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | up-regulates quantity by expression
transcriptional regulation
|
COL2A1 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980415 |
Since Sox9 also contains a potent transcription activation domain, it is a typical transcription factor. Two other members of the Sox family, L-Sox5 and Sox6, also bind to the 48-bp Col2a1 enhancer and together with Sox9 activate this enhancer as well as the endogenous Col2a1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | down-regulates quantity by repression
transcriptional regulation
|
HBG1 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251810 |
|
|
Homo sapiens |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 20395365 |
BCL11A and SOX6 co-occupy the human beta-globin cluster along with GATA1, and cooperate in silencing gamma-globin transcription in adult human erythroid progenitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SOX6
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