| + |
HECTD3 | down-regulates activity 
polyubiquitination
|
CASP8 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272077 |
Lys231 |
KVYQMKSkPRGYCLI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24287696 |
HECTD3, a new E3 ubiquitin ligase, interacts with caspase-8 death effector domains and ubiquitinates caspase-8 with K63-linked polyubiquitin chains that do not target caspase-8 for degradation but decrease the caspase-8 activation. HECTD3 ubiquitinates caspase-8 with K63-linked polyubiquitin chains at K215. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates activity 
phosphorylation
|
HECTD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272330 |
Thr157 |
ARLVPIDtPNHLQRQ |
Homo sapiens |
KYSE-30 Cell |
| pmid |
sentence |
| 28716524 |
HECTD3 binds and ubiquitinates caspase-9.Phosphorylation of HECTD3 by ERK is required for the association of HECTD3 and caspase-9. HECTD3 suppressing caspase-9 activation is dependent on T157 phosphorylation by ERK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECTD3 | down-regulates activity
polyubiquitination
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272329 |
|
|
Homo sapiens |
KYSE-30 Cell |
| pmid |
sentence |
| 28716524 |
HECTD3 binds and ubiquitinates caspase-9.HECTD3 inhibits caspase-9 oligomerization and association with Apaf-1. HECTD3 suppressing caspase-9 activation is dependent on T157 phosphorylation by ERK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECTD3 | down-regulates quantity by destabilization
polyubiquitination
|
TRIOBP |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271770 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18194665 |
Here, we identify a novel Tara-binding protein HECTD3, a putative member of HECT E3 ubiquitin ligases. HECTD3 directly binds Tara in vitro and forms a complex with Tara in vivo. Overexpression of HECTD3 enhances the ubiquitination of Tara in vivo and promotes the turnover of Tara, whereas depletion of HECTD3 by small interfering RNA decreases Tara degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
HECTD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271280 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECTD3 | up-regulates quantity by stabilization
polyubiquitination
|
MALT1 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272096 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23358872 |
HECTD3 promotes MALT1 ubiquitination with nondegradative polyubiquitin chains by direct interacting with the MALT1 through its N-terminal destruction of cyclin domain. HECTD3 does not target MALT1 for degradation but stabilize it. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECTD3 | down-regulates quantity by destabilization
polyubiquitination
|
STX8 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271772 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18821010 |
Our co-immunoprecipitation experiments show that Syntaxin 8 directly interacts with HECTd3 and that the overexpression of HECTd3 promotes the ubiquitination of Syntaxin 8. Immunoprecipitates probed with the anti-ubiquitin (Santa Cruz) antibody could be recognized by the anti-ubiquin antibody (Fig. 3a), indicating that the shift of the His-syntaxin 8 protein bands were caused by polyubiquitin conjugations. Our data suggest that HECTd3 may function as an E3 ubiquitin-protein ligase to promote the ubiquitination and degradation of Syntaxin 8 through the proteasome pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECTD3 | down-regulates quantity by destabilization
polyubiquitination
|
RAF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272328 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28636940 |
By western blot, we observed robust degradation of endogenous native CRAF in untransformed HEK293 cells treated with control siRNA 24 hr after the addition of AUY922, but this was substantially reduced in cells in which HECTD3 was knocked down, confirming that endogenous CRAF is a bona fide degradation target of HECTD3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HECTD3
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