3.0
Summary
| Name |  RNF43View Modifications |
| Full Name | E3 ubiquitin-protein ligase RNF43 |
| Synonyms | RING finger protein 43 |
| Primary ID | Q68DV7 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RNF43 | down-regulates quantity by destabilization 
ubiquitination
|
CDH1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
RNF43 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF43 | up-regulates
relocalization
|
FZD2 | 0.313 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF43 | down-regulates quantity by destabilization
ubiquitination
|
TP53 | |
| Publications: | 1 | Organism: | Homo Sapiens | |