3.0
Summary
| Name |  ARHGAP17View Modifications |
| Full Name | Rho GTPase-activating protein 17 |
| Synonyms | Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1 | RICH1 |
| Primary ID | Q68EM7 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | down-regulates activity 
phosphorylation
|
ARHGAP17 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKA | down-regulates activity
phosphorylation
|
ARHGAP17 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKC | down-regulates activity
phosphorylation
|
ARHGAP17 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIP10 | down-regulates activity
binding
|
ARHGAP17 | 0.516 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGAP17 | up-regulates activity 
guanine nucleotide exchange factor
|
RAC1 | 0.546 |
| Publications: | 1 | Organism: | Homo Sapiens | |