3.0
Summary
| Name |  ZNF746View Modifications |
| Full Name | Zinc finger protein 746 |
| Synonyms | Parkin-interacting substrate, PARIS | PARIS |
| Primary ID | Q6NUN9 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PINK1 | down-regulates quantity by destabilization 
phosphorylation
|
ZNF746 | 0.379 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ABL1 | up-regulates activity 
phosphorylation
|
ZNF746 | 0.319 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKN | down-regulates quantity by destabilization
polyubiquitination, ubiquitination
|
ZNF746 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ZNF746 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |