Summary

Name ZNF322
Full Name Zinc finger protein 322
Synonyms Zinc finger protein 322A, Zinc finger protein 388, Zinc finger protein 489 | ZNF322A, ZNF388, ZNF489
Primary ID Q6U7Q0
Links - -
Type protein
Relations 9
Function Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AKTup-regulates activity img/direct-activation.png phosphorylation ZNF322 0.2
Publications: 4 Organism: Homo Sapiens
+ GSK3Bdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ZNF322 0.2
Publications: 1 Organism: Homo Sapiens
+ CSNK1Ddown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ZNF322 0.2
Publications: 1 Organism: Homo Sapiens
+ ZNF322up-regulates quantity by expression img/direct-activation.png transcriptional regulation POU5F1 0.2
Publications: 1 Organism: Mus Musculus
+ FBXW7down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ZNF322 0.2
Publications: 1 Organism: Homo Sapiens
+ ZNF322up-regulates quantity by expression img/direct-activation.png transcriptional regulation NANOG 0.2
Publications: 1 Organism: Mus Musculus