| + |
BDNF | up-regulates 
|
Synaptic_plasticity |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32603820 |
BDNF is a central driver of synaptic plasticity and memory formation and its decreased levels may contribute to the degeneration of specific neuronal populations and progressive atrophy of neurons in the AD-affected brain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| Pathways: | Dopaminergic Synapse, GABAergic synapse , Rett syndrome |
| + |
MECP2/SIN3A/HDAC complex | down-regulates quantity by repression 
transcriptional regulation
|
BDNF |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265071 |
|
|
Mus musculus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 14593184 |
Moreover, increased Bdnf transcription involves dissociation of the MeCP2–histone deacetylase–mSin3A repression complex from its promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
REST | down-regulates quantity by repression 
transcriptional regulation
|
BDNF |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255075 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21832040 |
HIPPI could bind to the promoter of REST and increased its expression in neuronal as well as non-neuronal cells. Such activation of REST down-regulated expression of REST target genes, such as brain-derived neurotrophic factor (BDNF) or proenkephalin (PENK). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ANKRD11 | up-regulates quantity by expression 
transcriptional regulation
|
BDNF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266732 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
Neurite growth-related genes such as Trkb, Bdnf, Gap43, Coronin 1B, and Rab13 are downregulated in ANKRD11-deficient neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
BDNF |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254023 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18599437 |
MeCP2 is involved in gene silencing and known to affect the activity of brain-derived neurotrophic factor (BDNF) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
KDM5C | down-regulates quantity by repression
transcriptional regulation
|
BDNF |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264315 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31691806 |
The KDM5C decrease was associated with a lack of repression of downstream target genes Scn2a, Syn1 and Bdnf in the embryonic brain of Arx-null mice. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
OPTN | up-regulates quantity by expression
transcriptional regulation
|
BDNF |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259878 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22194658 |
SiRNA effectively downregulated optineurin expression in RGC-5 and PC12 stable transfected cells. Optineurin siRNA significantly inhibited cell growth and increased apoptosis in RGC-5 and PC12 cells. Microarray analysis identified 112 differentially expressed genes in optineurin siRNA transfected RGC-5 cells. Quantitative real-time PCR and western blot confirmed that the expression of brain-derived neurotrophic factor (Bdnf), neurotrophin-3(Ntf3), synaptosomal-associated protein 25(Snap25), and neurofilament, light polypeptide(Nefl) was significantly downregulated in RGC-5 and PC12 cells transfected with optineurin siRNA. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CREB1 | up-regulates quantity
transcriptional regulation
|
BDNF |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32603820 |
Brain-derived neurotrophic factor (BDNF) is a critical molecule for learning and memory. Brain BDNF levels correlate with cognitive status. Activation of CREB facilitates the transcription of crucial proteins for activity-dependent plasticity particularly BDNF. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| Pathways: | Dopaminergic Synapse, GABAergic synapse , Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
BDNF |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264540 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 14593183 |
We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Rett syndrome |
| + |
BDNF | up-regulates
binding
|
NTRK2 |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-31597 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7679912 |
Its interactions with trkb can be distinguished from those of brain-derived neurotrophic factor (bdnf) with trkb |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
3.0
BDNF
- 
- 