Relation Results

Summary

Name BDNF
Full Name Brain-derived neurotrophic factor
Synonyms BDNF, Abrineurin
Primary ID P23560
Links - -
Type protein
Relations 10
Pathways Dopaminergic Synapse, GABAergic synapse , Rett syndrome
Function Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and di ...
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Type: Score: Layout: SPV 
0.3730.4240.20.4750.2750.2810.4930.70.817MECP2/SIN3A/HDAC complexBDNFRESTANKRD11MECP2KDM5COPTNCREB1Synaptic_plasticityNTRK2

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Relations
Regulator
Mechanism
target
score ℹ
+ MECP2/SIN3A/HDAC complexdown-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BDNF 0.373
Identifier Residue Sequence Organism Cell Line
SIGNOR-265071 Mus musculus Cerebral Cortical Neuron
pmid sentence
Moreover, increased Bdnf transcription involves dissociation of the MeCP2–histone deacetylase–mSin3A repression complex from its promoter.
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ RESTdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BDNF 0.424
Identifier Residue Sequence Organism Cell Line
SIGNOR-255075 Homo sapiens
pmid sentence
HIPPI could bind to the promoter of REST and increased its expression in neuronal as well as non-neuronal cells. Such activation of REST down-regulated expression of REST target genes, such as brain-derived neurotrophic factor (BDNF) or proenkephalin (PENK).
Publications: 1 Organism: Homo Sapiens
+ ANKRD11up-regulates quantity by expression img/direct-activation.png transcriptional regulation BDNF 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266732 Mus musculus
pmid sentence
Neurite growth-related genes such as Trkb, Bdnf, Gap43, Coronin 1B, and Rab13 are downregulated in ANKRD11-deficient neurons. 
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ MECP2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BDNF 0.475
Identifier Residue Sequence Organism Cell Line
SIGNOR-254023 Mus musculus
pmid sentence
MeCP2 is involved in gene silencing and known to affect the activity of brain-derived neurotrophic factor (BDNF)
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ KDM5Cdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BDNF 0.275
Identifier Residue Sequence Organism Cell Line
SIGNOR-264315 Mus musculus
pmid sentence
The KDM5C decrease was associated with a lack of repression of downstream target genes Scn2a, Syn1 and Bdnf in the embryonic brain of Arx-null mice.
Publications: 1 Organism: Mus Musculus
+ OPTNup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BDNF 0.281
Identifier Residue Sequence Organism Cell Line
SIGNOR-259878 Mus musculus
pmid sentence
SiRNA effectively downregulated optineurin expression in RGC-5 and PC12 stable transfected cells. Optineurin siRNA significantly inhibited cell growth and increased apoptosis in RGC-5 and PC12 cells. Microarray analysis identified 112 differentially expressed genes in optineurin siRNA transfected RGC-5 cells. Quantitative real-time PCR and western blot confirmed that the expression of brain-derived neurotrophic factor (Bdnf), neurotrophin-3(Ntf3), synaptosomal-associated protein 25(Snap25), and neurofilament, light polypeptide(Nefl) was significantly downregulated in RGC-5 and PC12 cells transfected with optineurin siRNA.
Publications: 1 Organism: Mus Musculus
+ CREB1up-regulates quantity img/direct-activation.png transcriptional regulation BDNF 0.493
Identifier Residue Sequence Organism Cell Line
SIGNOR-265062 Homo sapiens
pmid sentence
Brain-derived neurotrophic factor (BDNF) is a critical molecule for learning and memory. Brain BDNF levels correlate with cognitive status. Activation of CREB facilitates the transcription of crucial proteins for activity-dependent plasticity particularly BDNF.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Dopaminergic Synapse, GABAergic synapse , Rett syndrome
+ MECP2down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BDNF 0.475
Identifier Residue Sequence Organism Cell Line
SIGNOR-264540 Rattus norvegicus
pmid sentence
We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene.
Publications: 1 Organism: Rattus Norvegicus
Pathways:Rett syndrome
+ BDNFup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265063 Homo sapiens
pmid sentence
BDNF is a central driver of synaptic plasticity and memory formation and its decreased levels may contribute to the degeneration of specific neuronal populations and progressive atrophy of neurons in the AD-affected brain
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Dopaminergic Synapse, GABAergic synapse , Rett syndrome
+ BDNFup-regulates img/direct-activation.png binding NTRK2 0.817
Identifier Residue Sequence Organism Cell Line
SIGNOR-31597 Homo sapiens
pmid sentence
Its interactions with trkb can be distinguished from those of brain-derived neurotrophic factor (bdnf) with trkb
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
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