| + |
CAMK2A | up-regulates 
phosphorylation
|
RIMS1 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103886 |
Ser242 |
PSAPPDRsKGAEPSQ |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12871946 |
Two serine residues in rim1 (ser-241 and ser-287) and one serine residue in rim2 (ser-335) were required for 14-3-3 binding. Incubation with ca2+/calmodulin-dependent protein kinase ii greatly stimulated the interaction of recombinant n-terminal rim but not the s241/287a mutant with 14-3-3, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103890 |
Ser288 |
NGKGALKsERKRVPK |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12871946 |
Two serine residues in rim1 (ser-241 and ser-287) and one serine residue in rim2 (ser-335) were required for 14-3-3 binding. Incubation with ca2+/calmodulin-dependent protein kinase ii greatly stimulated the interaction of recombinant n-terminal rim but not the s241/287a mutant with 14-3-3, |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| Pathways: | Neurotransmitters release |
| + |
RIMBP3C | down-regulates activity 
binding
|
RIMS1 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264362 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMBP3 | down-regulates activity
binding
|
RIMS1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264360 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMS1 | up-regulates activity
relocalization
|
UNC13B |
0.791 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264385 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
RIMS1 | up-regulates activity
relocalization
|
RAB3A |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264381 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
TSPOAP1 | down-regulates activity
binding
|
RIMS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264363 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMBP3B | down-regulates activity
binding
|
RIMS1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264364 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RIMS1 | up-regulates activity
relocalization
|
RAB3C |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264382 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIMS1 | up-regulates activity
binding
|
CACNA1D |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264358 |
|
|
Homo sapiens |
Cochlear Hair Cell |
| pmid |
sentence |
| 28642685 |
Here, we report an interaction of the C2B domain of RIM2α and RIM3γ with the C-terminus of the pore-forming α-subunit of CaV1.3 channels (CaV1.3α1), which mediate stimulus-secretion coupling at the ribbon synapses of cochlear inner hair cells (IHCs). In conclusion, we propose that RIM2α and RIM3γ directly interact with the C-terminus of the pore-forming subunit of CaV1.3 Ca2+ channels and positively regulate their plasma membrane expression in HEK293 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIMBP2 | down-regulates activity
binding
|
RIMS1 |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264361 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 11988172 |
SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
RIMS1
- 
- 