Summary

Name CD163
Full Name Scavenger receptor cysteine-rich type 1 protein M130
Synonyms Hemoglobin scavenger receptor | M130
Primary ID Q86VB7
Links - -
Type protein
Relations 5
Function Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; FUNCTION

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation CD163 0.328
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CD163 0.31
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png binding hb:hp 0.735
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CD163 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CD163 0.263
Publications: 1 Organism: Homo Sapiens