3.0
Summary
| Name |  CD163View Modifications |
| Full Name | Scavenger receptor cysteine-rich type 1 protein M130 |
| Synonyms | Hemoglobin scavenger receptor | M130 |
| Primary ID | Q86VB7 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; FUNCTION |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA |
phosphorylation
|
CD163 | 0.328 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK2B | up-regulates activity 
phosphorylation
|
CD163 | 0.311 |
| Publications: | 1 | Organism: | In Vitro | |
| + | HBA1 | up-regulates activity
binding
|
CD163 | 0.262 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CD163 | down-regulates quantity by destabilization 
binding
|
hb:hp | 0.735 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HBB | up-regulates activity
binding
|
CD163 | 0.417 |
| Publications: | 1 | Organism: | Homo Sapiens | |