Summary

Name ADSS1
Full Name Adenylosuccinate synthetase isozyme 1
Synonyms AMPSase 1, AdSS 1, Adenylosuccinate synthetase, basic isozyme, Adenylosuccinate synthetase, muscle isozyme, M-type adenylosuccinate synthetase, Adenylosuccinate synthetase-like 1, AdSSL1, IMP--aspartate ligase 1 | ADSSL1
Primary ID Q8N142
Links - -
Type protein
Relations 5
Pathways Aspartate and asparagine metabolism, Nucleotide Biosynthesis
Function Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

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Relations

Regulator Mechanism target score ℹ
+ ADSS1up-regulates img/indirect-activation.png Nucleotide_synthesis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ ADSS1down-regulates quantity img/direct_inhibition.png chemical modification IMP 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ ADSS1up-regulates quantity img/direct-activation.png chemical modification N(6)-(1,2-dicarboxylatoethyl)-AMP(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ ADSS1down-regulates quantity img/direct_inhibition.png chemical modification L-aspartate(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Nucleotide Biosynthesis
+ ADSS1up-regulates quantity img/direct-activation.png chemical modification GDP 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis