4.0
Summary
| Name |  PELI3View Modifications |
| Full Name | E3 ubiquitin-protein ligase pellino homolog 3 |
| Synonyms | Pellino-3 |
| Primary ID | Q8N2H9 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Pathways | CROHN_DENDR, CROHN_IEC, ULCERATIVE_COLITIS_IBD |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PELI3 | down-regulates activity 
ubiquitination
|
IRF4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PELI3 | up-regulates 
|
ELK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PELI3 | up-regulates activity 
ubiquitination
|
RIPK2 | 0.374 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PELI3 | up-regulates
ubiquitination
|
IRAK1 | 0.729 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRAK1 | up-regulates
phosphorylation
|
PELI3 | 0.729 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PELI3 | up-regulates
|
JUN | 0.278 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PELI3 | down-regulates quantity
ubiquitination
|
TRAF6 | 0.63 |
| Publications: | 1 | Organism: | Homo Sapiens | |