Summary

Name PELI3
Full Name E3 ubiquitin-protein ligase pellino homolog 3
Synonyms Pellino-3
Primary ID Q8N2H9
Links - -
Type protein
Relations 5
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.

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Relations

Regulator Mechanism target score ℹ
+ PELI3up-regulates img/direct-activation.png ubiquitination IRAK1 0.718
Publications: 1 Organism: Homo Sapiens
+ PELI3up-regulates img/indirect-activation.png JUN 0.282
Publications: 1 Organism: Homo Sapiens
+ PELI3up-regulates img/indirect-activation.png ELK1 0.2
Publications: 1 Organism: Homo Sapiens
+ IRAK1up-regulates img/direct-activation.png phosphorylation PELI3 0.718
Publications: 2 Organism: Homo Sapiens