4.0
Summary
| Name |  RIPK2View Modifications |
| Full Name | Receptor-interacting serine/threonine-protein kinase 2 |
| Synonyms | CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARD-containing IL-1 beta ICE-kinase, RIP-like-interacting CLARP kinase, Receptor-interacting protein 2, RIP-2, Tyrosine-protein kinase RIPK2, 2.7.10.2 | CARDIAK, RICK, RIP2 |
| Primary ID | O43353 |
| Links |  -  -  |
| Type | protein |
| Relations | 21 |
| Pathways | IBD_DENDRITIC CELLS, IBD_IEC |
| Function | Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | XIAP | up-regulates activity 
ubiquitination
|
RIPK2 | 0.623 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LUBAC | up-regulates activity
polyubiquitination
|
RIPK2 | 0.529 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LRRK2 | up-regulates activity
phosphorylation
|
RIPK2 | 0.376 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK2 | up-regulates activity
phosphorylation
|
RIPK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK2 | up-regulates
phosphorylation
|
IRF5 | 0.309 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PELI3 | up-regulates activity
ubiquitination
|
RIPK2 | 0.374 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNF | up-regulates quantity by expression 
transcriptional regulation
|
RIPK2 | 0.361 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRF4 | down-regulates activity 
binding
|
RIPK2 | 0.484 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATG16L1 | down-regulates activity
binding
|
RIPK2 | 0.393 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ITCH | up-regulates activity
binding
|
RIPK2 | 0.523 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOD2 | up-regulates activity
binding
|
RIPK2 | 0.767 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK2 | up-regulates activity
phosphorylation
|
MAPK1 | 0.297 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK2 | up-regulates activity
binding
|
TRAF6 | 0.68 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK2 | up-regulates activity
phosphorylation
|
MAP2K7 | 0.43 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | hsa-miR-150-5p | down-regulates quantity by repression
post transcriptional regulation
|
RIPK2 | 0.4 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | BIRC3 | up-regulates activity
polyubiquitination
|
RIPK2 | 0.789 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZNRF4 | down-regulates quantity by destabilization
ubiquitination
|
RIPK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IFNG | up-regulates quantity by expression
transcriptional regulation
|
RIPK2 | 0.286 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK2 | up-regulates activity
|
IKBKG | 0.673 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BIRC2 | up-regulates activity
polyubiquitination
|
RIPK2 | 0.646 |
| Publications: | 1 | Organism: | Homo Sapiens | |