Summary

Name LFNG
Full Name Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Synonyms O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Primary ID Q8NES3
Links - -
Type protein
Relations 10
Function Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ LFNGdown-regulates img/direct_inhibition.png binding JAG1 0.501
Publications: 1 Organism: Homo Sapiens
+ LFNGup-regulates img/direct-activation.png glycosylation, binding NOTCH1 0.748
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ LFNGup-regulates img/direct-activation.png binding NOTCH2 0.685
Publications: 1 Organism: Homo Sapiens
+ LFNGup-regulates img/direct-activation.png binding DLL3 0.461
Publications: 1 Organism: Homo Sapiens
+ LFNGup-regulates img/direct-activation.png binding DLL1 0.46
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation LFNG 0.2
Publications: 1 Organism: Homo Sapiens
+ LFNGdown-regulates img/direct_inhibition.png binding NOTCH2 0.685
Publications: 1 Organism: Homo Sapiens
+ NOTCH1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LFNG 0.748
Publications: 2 Organism: Homo Sapiens, Mus Musculus