3.0
Summary
| Name |  NOXO1View Modifications |
| Full Name | NADPH oxidase organizer 1 |
| Synonyms | NADPH oxidase regulatory protein, Nox organizer 1, Nox-organizing protein 1, SH3 and PX domain-containing protein 5 | P41NOX, SH3PXD5 |
| Primary ID | Q8NFA2 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PKC | up-regulates activity 
phosphorylation
|
NOXO1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCA | up-regulates
phosphorylation
|
NOXO1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOXO1 | up-regulates activity
relocalization
|
NOXA1 | 0.77 |
| Publications: | 1 | Organism: | Homo Sapiens | |