Name LNX1
Full Name E3 ubiquitin-protein ligase LNX
Synonyms Ligand of Numb-protein X 1, Numb-binding protein 1, PDZ domain-containing RING finger protein 2 | LNX, PDZRN2
Primary ID Q8TBB1
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.



Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png ubiquitination NUMB 0.36
Publications: 1 Organism: Homo Sapiens