Summary

Name LNX1
Full Name E3 ubiquitin-protein ligase LNX
Synonyms Ligand of Numb-protein X 1, Numb-binding protein 1, PDZ domain-containing RING finger protein 2 | LNX, PDZRN2
Primary ID Q8TBB1
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png ubiquitination NUMB 0.36
Publications: 1 Organism: Homo Sapiens