Relation Results

Summary

Name BCR
Full Name Breakpoint cluster region protein
Synonyms Renal carcinoma antigen NY-REN-26 | BCR1, D22S11
Primary ID P11274
Links - -
Type protein
Relations 17
Function Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating pro ...
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Type: Score: Layout: SPV 
0.3070.3320.370.20.2680.5950.3310.365BCRYWHAQYWHAZFESBCR-ABLLNX1RAC1PTPN1MYC

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ BCR img/unknown.png phosphorylation YWHAQ 0.307
Identifier Residue Sequence Organism Cell Line
SIGNOR-250594 Ser232 LTLWTSDsAGEECDA in vitro
pmid sentence
We show here that BCR interacts with at least five isoforms of 14-3-3 in vivo and phosphorylates 14-3-3tau on Ser233 and to a lesser extent 14-3-3zeta on Thr233
Publications: 1 Organism: In Vitro
+ BCR img/unknown.png phosphorylation YWHAZ 0.332
Identifier Residue Sequence Organism Cell Line
SIGNOR-250595 Thr232 LTLWTSDtQGDEAEA in vitro
pmid sentence
We show here that BCR interacts with at least five isoforms of 14-3-3 in vivo and phosphorylates 14-3-3tau on Ser233 and to a lesser extent 14-3-3zeta on Thr233
Publications: 1 Organism: In Vitro
+ FESdown-regulates activity img/direct_inhibition.png phosphorylation BCR 0.37
Identifier Residue Sequence Organism Cell Line
SIGNOR-251136 Tyr177 ADAEKPFyVNVEFHH Homo sapiens HEK-293 Cell
pmid sentence
Mutagenesis of BCR Tyr-177 to Phe completely abolished FES-induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES. Co-expression of BCR and FES in human 293T cells stimulated the tyrosine autophosphorylation of FES. By contrast, tyrosine phosphorylation of BCR by FES suppressed BCR serine/threonine kinase activity toward the 14-3-3 protein and BCR substrate, BAP-1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-251137 Tyr246 SCGVDGDyEDAELNP Homo sapiens HEK-293 Cell
pmid sentence
In the present study, we demonstrate that BCR Tyr-246 and at least one of the closely spaced tyrosine residues, Tyr-279, Tyr-283, and Tyr-289 (3Y cluster), are phosphorylated by FES both in vitro and in 32Pi-labeled cells. Co-expression of BCR and FES in human 293T cells stimulated the tyrosine autophosphorylation of FES. By contrast, tyrosine phosphorylation of BCR by FES suppressed BCR serine/threonine kinase activity toward the 14-3-3 protein and BCR substrate, BAP-1. 
Publications: 2 Organism: Homo Sapiens
+ BCR-ABLdown-regulates activity img/direct_inhibition.png phosphorylation BCR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-40611 Tyr177 ADAEKPFyVNVEFHH Homo sapiens
pmid sentence
We have previously demonstrated that the bcr protein is tyrosine phosphorylated within first-exon sequences by the bcr-abl oncoprotein. Here we report that in addition to tyrosine 177 (y-177), y-360 and y283 are phosphorylated in bcr-abl proteins in vitro. Tyrosine-phosphorylated bcr, phosphorylated in vitro by bcr-abl, was greatly inhibited in its serine/threonine kinase activity, impairing both auto- and transkinase activities of bcr.
Identifier Residue Sequence Organism Cell Line
SIGNOR-260829 Tyr328 YSPRSFEdCGGGYTP Homo sapiens
pmid sentence
Thus, we propose that the phosphorylation of tyrosine 328 and 360 within Bcr by Bcr ± Abl will drastically interfere with Bcr's kinase role in either signal transduction or some other cellular mechanism.
Identifier Residue Sequence Organism Cell Line
SIGNOR-260828 Tyr360 YSPRSFEdCGGGYTP Homo sapiens
pmid sentence
Thus, we propose that the phosphorylation of tyrosine 328 and 360 within Bcr by Bcr-Abl will drastically interfere with Bcr's kinase role in either signal transduction or some other cellular mechanism.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262530 Tyr360 VSPSPTTyRMFRDKS Chlorocebus aethiops
pmid sentence
These results indicate that tyrosine phosphorylation of Bcr by Bcr-Abl inhibits Bcr’s serine/threonine kinase activity.
Publications: 4 Organism: Homo Sapiens, Chlorocebus Aethiops
+ FESdown-regulates img/direct_inhibition.png phosphorylation BCR 0.37
Identifier Residue Sequence Organism Cell Line
SIGNOR-45330 Tyr246 SCGVDGDyEDAELNP Homo sapiens HEK-293 Cell
pmid sentence
In the present study, we demonstrate that bcr tyr-246 and at least one of the closely spaced tyrosine residues, tyr-279, tyr-283, and tyr- 289 (3y cluster), are phosphorylated by fes both in vitro and in 32p(i)- labeled cells. tyrosine phosphorylation of bcr by fes suppressed bcr serine/threonine kinase activity toward the 14-3-3 protein and bcr substrate, bap-1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-45334 Tyr279 PPLEYQPyQSIYVGG Homo sapiens HEK-293 Cell
pmid sentence
In the present study, we demonstrate that bcr tyr-246 and at least one of the closely spaced tyrosine residues, tyr-279, tyr-283, and tyr- 289 (3y cluster), are phosphorylated by fes both in vitro and in 32p(i)- labeled cells. tyrosine phosphorylation of bcr by fes suppressed bcr serine/threonine kinase activity toward the 14-3-3 protein and bcr substrate, bap-1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-45343 Tyr283 YQPYQSIyVGGMMEG Homo sapiens HEK-293 Cell
pmid sentence
In the present study, we demonstrate that bcr tyr-246 and at least one of the closely spaced tyrosine residues, tyr-279, tyr-283, and tyr- 289 (3y cluster), are phosphorylated by fes both in vitro and in 32p(i)- labeled cells. tyrosine phosphorylation of bcr by fes suppressed bcr serine/threonine kinase activity toward the 14-3-3 protein and bcr substrate, bap-1.
Publications: 3 Organism: Homo Sapiens
+ BCR-ABLdown-regulates img/direct_inhibition.png phosphorylation BCR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-40615 Tyr283 YQPYQSIyVGGMMEG Homo sapiens Leukemia Cell
pmid sentence
We have previously demonstrated that the bcr protein is tyrosine phosphorylated within first-exon sequences by the bcr-abl oncoprotein. Here we report that in addition to tyrose 177 (y-177), y-360 and y283 are phosphorylated in bcr-abl proteins in vitro. Tyrosine-phosphorylated bcr, phosphorylated in vitro by bcr-abl, was greatly inhibited in its serine/threonine kinase activity, impairing both auto- and transkinase activities of bcr.
Identifier Residue Sequence Organism Cell Line
SIGNOR-40619 Tyr360 VSPSPTTyRMFRDKS Homo sapiens Leukemia Cell
pmid sentence
We have previously demonstrated that the bcr protein is tyrosine phosphorylated within first-exon sequences by the bcr-abl oncoprotein. Here we report that in addition to tyrose 177 (y-177), y-360 and y283 are phosphorylated in bcr-abl proteins in vitro. Tyrosine-phosphorylated bcr, phosphorylated in vitro by bcr-abl, was greatly inhibited in its serine/threonine kinase activity, impairing both auto- and transkinase activities of bcr.
Publications: 2 Organism: Homo Sapiens
+ LNX1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination BCR 0.268
Identifier Residue Sequence Organism Cell Line
SIGNOR-272903 Homo sapiens HEK-293 Cell
pmid sentence
We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous substrates, PDZ-binding kinase (PBK) and breakpoint cluster region protein (BCR), were confirmed in vivo.
Publications: 1 Organism: Homo Sapiens
+ BCRdown-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-260526 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
+ PTPN1down-regulates img/direct_inhibition.png dephosphorylation BCR 0.331
Identifier Residue Sequence Organism Cell Line
SIGNOR-56818 Homo sapiens
pmid sentence
These results illustrate selectivity in the effects of ptps in a cellular context and suggest that ptp1b may function as a specific, negative regulator of p210 bcr-abl signalling in vivo.
Publications: 1 Organism: Homo Sapiens
+ MYCup-regulates quantity by expression img/direct-activation.png transcriptional regulation BCR 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-272144 Homo sapiens K-562 Cell, LAMA-84 Cell
pmid sentence
In the present study we demonstrate that MYC and its partner MAX bind to the BCR promoter, leading to up-regulation of BCR and BCR/ABL1 at both transcriptional and protein levels.|Here we describe a regulatory pathway modulating BCR and BCR/ABL1 expression, showing that the BCR promoter is under the transcriptional control of the MYC/MAX heterodimer.
Publications: 1 Organism: Homo Sapiens
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