3.0
Summary
| Name |  PBKView Modifications |
| Full Name | Lymphokine-activated killer T-cell-originated protein kinase |
| Synonyms | Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase | TOPK |
| Primary ID | Q96KB5 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PBK |
phosphorylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PBK | up-regulates 
phosphorylation
|
PRDX1 | 0.264 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PBK | down-regulates activity 
phosphorylation
|
PTEN | 0.523 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PBK | up-regulates
phosphorylation
|
GPSM2 | 0.274 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 |
phosphorylation
|
PBK | 0.572 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CyclinB/CDK1 | up-regulates activity
phosphorylation
|
PBK | 0.572 |
| Publications: | 1 | |||
| + | CyclinB/CDK1 |
phosphorylation
|
PBK | 0.572 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LNX1 | down-regulates quantity by destabilization
ubiquitination
|
PBK | 0.383 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHFR | down-regulates quantity by destabilization
polyubiquitination
|
PBK | 0.352 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PBK |
phosphorylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |