+ |
STK26 | up-regulates activity
phosphorylation
|
ASAP3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272238 |
Thr545 |
HRFARRCtPEPQRLW |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
28808054 |
Here we show that MST4 phosphorylates ACAP4, an ARF6 GTPase-activating protein, at Thr545|Significantly, phosphorylation of Thr545 enables ACAP4 to interact with ezrin. Given the location of Thr545 between the GTPase-activating protein domain and the first ankyrin repeat, we reason that MST4 phosphorylation elicits a conformational change that enables ezrin-ACAP4 interaction. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EGFR | up-regulates activity
phosphorylation
|
ASAP3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272234 |
Tyr34 |
FAAKMPRyRGAALAR |
Homo sapiens |
Hep-G2 Cell |
pmid |
sentence |
23776207 |
How ACAP4 regulates membrane dynamics and curvature in response to EGF stimulation is unknown. Here, we show that phosphorylation of the N-terminal region of ACAP4, named the Bin, Amphiphysin, and RSV161/167 (BAR) domain, at Tyr34 is necessary for EGF-elicited membrane remodeling. |EGF stimulation of cells causes phosphorylation of ACAP4 at Tyr34, which subsequently promotes ACAP4 homodimer curvature. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ASAP3 | up-regulates activity
binding
|
ARHGEF6 |
0.298 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272235 |
|
|
Homo sapiens |
Hep-G2 Cell |
pmid |
sentence |
23776207 |
ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 4 (ACAP4) is an ADP-ribosylation factor 6 (ARF6) GTPase-activating protein essential for EGF-elicited cell migration. |The crystal structure of the catalytic core of ACAP4 in a complex with ARF6 reveals the structural determinants underlying ACAP4 selectivity and specificity as an ARF6 GTPase-activating protein |
|
Publications: |
1 |
Organism: |
Homo Sapiens |