+ |
STK26 | up-regulates activity
phosphorylation
|
ATG4B |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275833 |
Ser383 |
RLERFFDsEDEDFEI |
|
|
pmid |
sentence |
29232556 |
ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux. |
|
Publications: |
1 |
+ |
STK26 | up-regulates activity
phosphorylation
|
ASAP3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272238 |
Thr545 |
HRFARRCtPEPQRLW |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
28808054 |
Here we show that MST4 phosphorylates ACAP4, an ARF6 GTPase-activating protein, at Thr545|Significantly, phosphorylation of Thr545 enables ACAP4 to interact with ezrin. Given the location of Thr545 between the GTPase-activating protein domain and the first ankyrin repeat, we reason that MST4 phosphorylation elicits a conformational change that enables ezrin-ACAP4 interaction. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK26 | up-regulates
phosphorylation
|
EZR |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-185563 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
|
pmid |
sentence |
19386264 |
Activation of ezrin is mediated by initial pip2 binding and subsequent phosphorylation of threonine 567. Mst4 phosphorylates the regulatory t567 residue of ezrin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |