| + |
STK26 | up-regulates activity
phosphorylation
|
ATG4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278254 |
Ser383 |
RLERFFDsEDEDFEI |
Homo sapiens |
|
| pmid |
sentence |
| 29232556 |
MST4 Induced p-S383 of ATG4B Enhances GSC Autophagic Activity and Tumorigenicity.|MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275833 |
Ser383 |
RLERFFDsEDEDFEI |
|
|
| pmid |
sentence |
| 29232556 |
ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| + |
STK26 | up-regulates quantity by stabilization
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280141 |
Thr40 |
SGIHSGAtTTAPSLS |
Homo sapiens |
|
| pmid |
sentence |
| 34240584 |
In response to Wnt3a stimulation, the kinase MST4 directly phosphorylates \u03b2-catenin at Thr40 to block its Ser33 phosphorylation by GSK3\u03b2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK26 | up-regulates activity
phosphorylation
|
ASAP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272238 |
Thr545 |
HRFARRCtPEPQRLW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28808054 |
Here we show that MST4 phosphorylates ACAP4, an ARF6 GTPase-activating protein, at Thr545|Significantly, phosphorylation of Thr545 enables ACAP4 to interact with ezrin. Given the location of Thr545 between the GTPase-activating protein domain and the first ankyrin repeat, we reason that MST4 phosphorylation elicits a conformational change that enables ezrin-ACAP4 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK26 | up-regulates
phosphorylation
|
EZR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185563 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
|
| pmid |
sentence |
| 19386264 |
Activation of ezrin is mediated by initial pip2 binding and subsequent phosphorylation of threonine 567. Mst4 phosphorylates the regulatory t567 residue of ezrin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK26 | down-regulates activity
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278994 |
Thr83 |
KTANVPQtVPMRLRK |
Homo sapiens |
|
| pmid |
sentence |
| 32271880 |
Further, and consistent with our aforementioned finding that MST4 inactivates YAP in response to serum starvation, this stress condition enhanced the YAP\u2013MST4 interaction ( xref ).|Here, we revealed that the MST4 kinase-mediated Thr83 phosphorylation of YAP represents such an additional mechanism of YAP inactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |