| + |
PKA | up-regulates activity 
phosphorylation
|
RAP1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278057 |
Ser180 |
KKKPKKKsCLLL |
Homo sapiens |
Leukocyte |
| pmid |
sentence |
| 17068197 |
Rap1 is phosphorylated and activated by PKA in neutrophils and platelets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates activity 
phosphorylation
|
RAP1A |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250042 |
Ser180 |
KKKPKKKsCLLL |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 9867809 |
Phosphorylation of Rap1A by PKA abolished its binding activity to CRR. a mutant Rap1A(S180E), whose sole PKA phosphorylation residue, Ser-180, was substituted by an acidic residue, Glu, to mimic its phosphorylated form, failed to suppress Ras-dependent Raf-1 activation in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
RAP1GDS1 | up-regulates
binding
|
RAP1A |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171482 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21242305 |
Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF5 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1A |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262682 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21791615 |
We found here that cAMP-dependent activation of Epac1 and Rap1 but not PKA is able to activate CaMKI to mediate Ser47 (S47) phosphorylation in GCM1. Epac1 and Epac2 proteins were identified as cAMP-binding proteins with guanine nucleotide exchange factor (GEF) activities for the small GTPases, Rap1 and Rap2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST2 | down-regulates quantity by repression 
transcriptional regulation
|
RAP1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255508 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 19051271 |
we performed microarray analysis to compare the gene expression profiles in HGC-27 cells, with or without small interfering RNA (siRNA)-mediated depletion of TWIST. Our results showed that NF1, RAP1A, SRPX, RBL2, PFDN4, ILK, F2R, ERBB3, and MYB were up-regulated, whereas AKR1C2, FOS, GDF15, NR2F1, ATM, and CTPS were down-regulated after TWIST depletion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF3 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1A |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263956 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10777494 |
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
RAP1A | up-regulates quantity
binding
|
PLCE1 |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278142 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 21478675 |
The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DEF6 | up-regulates activity
binding
|
RAP1A |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253365 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 26483383 |
Mechanistic studies revealed that SLAT interacts, through its PH domain, with a key component of inside-out signaling, namely the active form of the small GTPase Rap1 (which has two isoforms, Rap1A and Rap1B). This interaction has been further shown to facilitate the interdependent recruitment of Rap1 and SLAT to the T cell immunological synapse upon TCR engagement. Furthermore, a SLAT mutant lacking its PH domain drastically inhibited LFA-1 activation and CD4(+) T cell adhesion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF2 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1A |
0.792 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276609 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 24290981 |
Our data are consistent with a pathway involving the cAMP-mediated activation of Rapgef2, which then stimulates Rap1, leading to increases in B-Raf, MEK, and ERK activity.Increased intracellular concentrations of cAMP enhanced the Rapgef2-dependent activation of Rap1, which in turn associated with B-Raf to enable the activation of ERK and subsequent neuronal- and endocrine-specific cellular outcomes, such as induction of neuroendocrine-specific genes and extension of neuritic processes (neuritogenesis). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1A |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263954 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10777494 |
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
TWIST1 | down-regulates quantity by repression
transcriptional regulation
|
RAP1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255533 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 19051271 |
we performed microarray analysis to compare the gene expression profiles in HGC-27 cells, with or without small interfering RNA (siRNA)-mediated depletion of TWIST. Our results showed that NF1, RAP1A, SRPX, RBL2, PFDN4, ILK, F2R, ERBB3, and MYB were up-regulated, whereas AKR1C2, FOS, GDF15, NR2F1, ATM, and CTPS were down-regulated after TWIST depletion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1GAP | down-regulates activity
binding
|
RAP1A |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278054 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 22173489 |
Overexpression of Rap1GAP significantly inhibited Rap1 activation, ERK and Akt phosphorylation of HUVECs compared with pcDNA transfection controls |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates quantity
binding
|
RAP1A |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278143 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 21478675 |
The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1A | up-regulates activity
binding
|
AL/b2 integrin |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253362 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 12808052 |
The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration|Rap1 is a potent inside-out signal that increases LFA-1 adhesive activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RAP1A | up-regulates activity 
|
CAMK1 |
0.293 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21791615 |
The present study indicates that Epac1 and Rap1 are involved in activation of CaMKI for Ser47 phosphorylation in GCM1. We found here that cAMP-dependent activation of Epac1 and Rap1 but not PKA is able to activate CaMKI to mediate Ser47 (S47) phosphorylation in GCM1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1A | up-regulates activity
binding
|
BRAF |
0.678 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276608 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 24290981 |
Our data are consistent with a pathway involving the cAMP-mediated activation of Rapgef2, which then stimulates Rap1, leading to increases in B-Raf, MEK, and ERK activity.Increased intracellular concentrations of cAMP enhanced the Rapgef2-dependent activation of Rap1, which in turn associated with B-Raf to enable the activation of ERK and subsequent neuronal- and endocrine-specific cellular outcomes, such as induction of neuroendocrine-specific genes and extension of neuritic processes (neuritogenesis). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
RAP1A
- 
- 