3.0
Summary
| Name |  RAP1BView Modifications |
| Full Name | Ras-related protein Rap-1b |
| Synonyms | GTP-binding protein smg p21B |
| Primary ID | P61224 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates 
phosphorylation
|
RAP1B | 0.504 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAPGEF4 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1B | 0.804 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | RAP1GDS1 | up-regulates
binding
|
RAP1B | 0.423 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DEF6 | up-regulates activity
binding
|
RAP1B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAP1B | up-regulates activity
binding
|
AL/b2 integrin | 0.42 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | RAPGEF3 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1B | 0.707 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |