3.0
Summary
| Name |  PROX1View Modifications |
| Full Name | Prospero homeobox protein 1 |
| Synonyms | Homeobox prospero-like protein PROX1, PROX-1 | |
| Primary ID | Q92786 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Pathways | T-Lymphocyte: IFN gamma |
| Function | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKAA2 | down-regulates quantity by destabilization 
phosphorylation
|
PROX1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKAB1 | down-regulates quantity by destabilization
phosphorylation
|
PROX1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PROX1 | up-regulates quantity by stabilization 
|
HIF1A | 0.259 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin4-RBX1-DDB1 | down-regulates quantity by destabilization
polyubiquitination
|
PROX1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PROX1 | down-regulates quantity by repression 
transcriptional regulation
|
IFNG | 0.261 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PROX1 | down-regulates
|
RORC | 0.273 |
| Publications: | 1 | |||
| + | PROX1 | up-regulates
|
Epithelial-mesenchymal_transition | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DAB2IP | down-regulates quantity by repression
transcriptional regulation
|
PROX1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |