+ |
PRKAA1 | up-regulates
phosphorylation
|
PRKAB1 |
0.922 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-157553 |
Ser108 |
SKLPLTRsHNNFVAI |
Homo sapiens |
|
pmid |
sentence |
17728241 |
Mutation of serine 108 to alanine, an autophosphorylation site within the glycogen binding domain of the beta1 subunit, almost completely abolishes activation of ampk by a-769662 in cells and in vitro, while only partially reducing activation by amp |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKAB1 | up-regulates
phosphorylation
|
NOS3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-112367 |
Ser1177 |
TSRIRTQsFSLQERQ |
Homo sapiens |
|
pmid |
sentence |
11729179 |
Recently many investigators have shown that protein phosphorylation of enos by several serine/threonine kinases is a critical control step for no production by endothelial cells. Phosphorylation by amp kinase, akt (or protein kinase b), or protein kinase a on serine 1179 (bovine) or serine 1177 (human) of enos leads to enhanced activity of the enzyme and, thus, augmented production of no. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ULK2 | down-regulates
phosphorylation
|
PRKAB1 |
0.335 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-173092 |
|
|
Homo sapiens |
|
pmid |
sentence |
21460634 |
Ulk1/2 in turn phosphorylates all three subunits of ampk and thereby negatively regulates its activity |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKAB1 | up-regulates
phosphorylation
|
ULK1 |
0.511 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-173044 |
|
|
Homo sapiens |
|
pmid |
sentence |
21460634 |
Ampk and ulk1 interact and that the latter is phosphorylated by ampk. This phosphorylation leads to the direct activation of ulk1 by ampk bypassing mtor-inhibition |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKAB1 | form complex
binding
|
AMPK |
0.863 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-139164 |
|
|
Homo sapiens |
|
pmid |
sentence |
16054041 |
Gamma non-catalytic subunit mediates binding to amp, adp and atp, leading to activate or inhibit ampk: amp-binding results in allosteric activation of alpha catalytic subunit (prkaa1 or prkaa2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKAB1 | down-regulates
phosphorylation
|
RPTOR |
0.439 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-173041 |
|
|
Homo sapiens |
|
pmid |
sentence |
21460634 |
Ampk in turn inactivates mtorc1 directly by phosphorylating raptor and indirectly by phosphorylating tsc2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |