| + |
PKA | down-regulates activity 
phosphorylation
|
FRAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276058 |
Ser188 |
RLQQRRGsQPETRTG |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 16982607 |
Protein kinase A (PKA) was found to phosphorylate Ser188 in vitro as well as in intact cells. Importantly, activation of endogenous cAMP-coupled beta-adrenergic receptors with norepinephrine stimulated the phosphorylation of FRAT1 at Ser188. GSK-3 was also able to phosphorylate FRAT1 at Ser188 and other residues in vitro or when overexpressed in intact cells. Phosphorylation of Ser188 by PKA inhibited the ability of FRAT1 to activate beta-catenin-dependent transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates activity
phosphorylation
|
FRAT1 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276057 |
Ser188 |
RLQQRRGsQPETRTG |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 16982607 |
Protein kinase A (PKA) was found to phosphorylate Ser188 in vitro as well as in intact cells. Importantly, activation of endogenous cAMP-coupled beta-adrenergic receptors with norepinephrine stimulated the phosphorylation of FRAT1 at Ser188. GSK-3 was also able to phosphorylate FRAT1 at Ser188 and other residues in vitro or when overexpressed in intact cells. Phosphorylation of Ser188 by PKA inhibited the ability of FRAT1 to activate beta-catenin-dependent transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates
phosphorylation
|
FRAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149689 |
Ser188 |
RLQQRRGsQPETRTG |
Homo sapiens |
|
| pmid |
sentence |
| 16982607 |
Phosphorylation of ser188 by pka inhibited the ability of frat1 to activate beta-catenin-dependent transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FRAT1 | up-regulates activity 
binding
|
EIF2B5 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262835 |
|
|
|
|
| pmid |
sentence |
| 10481074 |
In contrast to the GS‐1 peptide, glycogen synthase and the eIF2B peptide, the GSK3‐catalysed phosphorylation of Tau was completely inhibited by FRATtide|This prevents GSK3 from phosphorylating and inhibiting glycogen synthase [2, 3] and protein synthesis initiation factor eIF2B |
|
| Publications: |
1 |
| + |
FRAT1 | up-regulates
binding
|
GSK3B |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58219 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9635432 |
The frat family consists of three members: frat-1, -2, and -3. It has been shown that different sites of frat-1 interact with gsk-3 and dvl-1 and that wnt-1 disintegrates the complex formation of frat-1, dvl-1, and axin, resulting in the activation of the wnt signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FRAT1 | up-regulates
binding
|
GSK3B/Axin/APC |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227994 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9635432 |
The frat family consists of three members: frat-1, -2, and -3. It has been shown that different sites of frat-1 interact with gsk-3 and dvl-1 and that wnt-1 disintegrates the complex formation of frat-1, dvl-1, and axin, resulting in the activation of the wnt signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL3 | up-regulates
binding
|
FRAT1 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97877 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12556519 |
These results indicate that cki epsilon-dependent phosphorylation of dvl enhances the formation of a complex of dvl-1 with frat-1 and that this complex leads to the activation of the wnt signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
3.0
FRAT1
- 
- 