+ |
JAK2 | up-regulates quantity
phosphorylation
|
ATOH1 |
0.346 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262201 |
Tyr80 |
CTARAAQyLLHSPEL |
Homo sapiens |
DAOY Cell |
pmid |
sentence |
29168692 |
We discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human SHH-type medulloblastoma. Phosphorylation of tyrosine 78 stabilizes Atoh1, increases Atoh1’s transcriptional activity, and is independent of canonical Jak2 signaling. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ATOH1 | up-regulates quantity by expression
transcriptional regulation
|
HES6 |
0.452 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253754 |
|
|
Homo sapiens |
|
pmid |
sentence |
17826772 |
Electrophoretic mobility shift assays and luciferase assays show that ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
HES5 | down-regulates quantity by repression
transcriptional regulation
|
ATOH1 |
0.417 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265145 |
|
|
Mus musculus |
Neuron |
pmid |
sentence |
30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
ATOH1 |
0.485 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265144 |
|
|
Mus musculus |
Neuron |
pmid |
sentence |
30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
ATOH1 | up-regulates quantity by expression
transcriptional regulation
|
MUC2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253755 |
|
|
Homo sapiens |
|
pmid |
sentence |
17000673 |
This study confirms the importance of HATH1 for the development of intestinal secretory cells. The results further suggest that HATH1 is an important factor in the up-regulation of MUC2 expression that occurs in mucinous cancers and signet ring carcinomas. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |