Summary

Name CELF1
Full Name CUGBP Elav-like family member 1
Synonyms CELF-1, 50 kDa nuclear polyadenylated RNA-binding protein, Bruno-like protein 2, CUG triplet repeat RNA-binding protein 1, CUG-BP1, CUG-BP- and ETR-3-like factor 1, Deadenylation factor CUG-BP, Embryo deadenylation element-binding protein homolog, EDEN-BP homolog, RNA-binding protein BRUNOL-2 | BRUNOL2, CUGBP, CUGBP1, NAB50
Primary ID Q92879
Links - -
Type protein
Relations 3
Function RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CELF1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation CELF1 0.409
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding EIF2S1 0.253
Publications: 1 Organism: Mus Musculus
Tissue: Liver