Summary

Name FGF13
Full Name Fibroblast growth factor 13
Synonyms FGF-13, Fibroblast growth factor homologous factor 2, FHF-2 | FHF2
Primary ID Q92913
Links - -
Type protein
Relations 9
Function Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (PubMed:15282281). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.416
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN5A 0.42
Publications: 1 Organism: Homo Sapiens
Tissue: Cardiac Muscle
+ down-regulates activity img/direct_inhibition.png binding SCN3A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN10A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN1A 0.282
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN11A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN4A 0.255
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding SCN2A 0.273
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN9A 0.366
Publications: 1 Organism: Homo Sapiens