| + |
CAMK2D | up-regulates activity 
phosphorylation
|
SCN8A |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275790 |
Ser561 |
PFLSRHNsKSSIFSF |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275791 |
Ser641 |
RRSVKRNsTVDCNGV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275792 |
Thr642 |
RSVKRNStVDCNGVV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CAMK2A | up-regulates activity
phosphorylation
|
SCN8A |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275784 |
Ser561 |
PFLSRHNsKSSIFSF |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275785 |
Ser641 |
RRSVKRNsTVDCNGV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275786 |
Thr642 |
RSVKRNStVDCNGVV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CAMK2G | up-regulates activity
phosphorylation
|
SCN8A |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275793 |
Ser561 |
PFLSRHNsKSSIFSF |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275794 |
Ser641 |
RRSVKRNsTVDCNGV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275795 |
Thr642 |
RSVKRNStVDCNGVV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CAMK2B | up-regulates activity
phosphorylation
|
SCN8A |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275787 |
Ser561 |
PFLSRHNsKSSIFSF |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275788 |
Ser641 |
RRSVKRNsTVDCNGV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275789 |
Thr642 |
RSVKRNStVDCNGVV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32611770 |
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates activity
phosphorylation
|
SCN8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275763 |
Thr1938 |
HREKKEStPSTASLP |
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 29642012 |
In vivo genetic manipulations demonstrate that GSK3β and Nav1.6 are molecular determinants of MSN excitability and that silencing of GSK3β prevents maladaptive plasticity of IC MSNs. In vitro studies reveal direct interaction of GSK3β with Nav1.6 and phosphorylation at Nav1.6T1936 by GSK3β. A GSK3β-Nav1.6T1936 competing peptide reduces MSNs excitability in IC, but not EC rats. These results identify GSK3β regulation of Nav1.6 as a biosignature of MSNs maladaptive plasticity. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ESR1 | up-regulates quantity by expression 
transcriptional regulation
|
SCN8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253476 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 22169964 |
In this study, quantitative real-time PCR analysis showed that the gene expression levels of TTX-S (Nav1.1 and Nav1.7) and TTX-R (Nav1.8 and Nav1.9) sodium channel subtypes were elevated in DRGs of αERKO and βERKO mice, whereas Nav1.6 mRNA decreased in αERKOs but showed no changes in βERKO mice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FGF11 | down-regulates activity 
binding
|
SCN8A |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253414 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20679355 |
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALM2 | down-regulates activity
binding
|
SCN8A |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266330 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11807557 |
Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL10 | down-regulates quantity by repression 
transcriptional regulation
|
SCN8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253501 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Spinal Ganglion |
| + |
NEDD4L | down-regulates quantity by destabilization
ubiquitination
|
SCN8A |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253461 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 23778145 |
The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FGF12 | down-regulates activity
binding
|
SCN8A |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253412 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20679355 |
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | up-regulates quantity by expression
transcriptional regulation
|
SCN8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253482 |
|
|
Mus musculus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 26112872 |
TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SCN8A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253406 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN8A | up-regulates
|
Action_potential |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26043074 |
The expression of voltage-gated sodium channels (NaVs) is a key feature for initiation and conduction of action potentials in excitable tissues and cells such as cardiac and skeletal muscle and neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF14 | down-regulates activity
binding
|
SCN8A |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253413 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20679355 |
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | up-regulates activity
|
SCN8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253491 |
|
|
Mus musculus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 26112872 |
TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FGF13 | down-regulates activity
binding
|
SCN8A |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253411 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20679355 |
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALM3 | down-regulates activity
binding
|
SCN8A |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266346 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11807557 |
Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALM1 | down-regulates activity
binding
|
SCN8A |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253410 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11807557 |
Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SCN8A
- 
- 