Summary

Name SCN8A
Full Name Sodium channel protein type 8 subunit alpha
Synonyms Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6 | MED
Primary ID Q9UQD0
Links - -
Type protein
Relations 27
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.275
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.286
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.276
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.283
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.318
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN8A 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png relocalization sodium(1+) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN8A 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Spinal Ganglion
+ up-regulates img/indirect-activation.png Action_potential 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SCN8A 0.33
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.47
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.47
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.559
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN8A 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SCN8A 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.418
Publications: 1 Organism: Homo Sapiens