Summary

Name SCN1A
Full Name Sodium channel protein type 1 subunit alpha
Synonyms Sodium channel protein brain I subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1 | NAC1, SCN1
Primary ID P35498
Links - -
Type protein
Relations 12
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN1A 0.262
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SCN1A 0.396
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN1A 0.272
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ down-regulates activity img/direct_inhibition.png binding SCN1A 0.373
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Action_potential 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SCN1A 0.262
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SCN1A 0.296
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN1A 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ down-regulates activity img/direct_inhibition.png binding SCN1A 0.264
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization sodium(1+) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN1A 0.283
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN1A 0.2
Publications: 1 Organism: Rattus Norvegicus