Summary

Name EPS15
Full Name Epidermal growth factor receptor substrate 15
Synonyms Protein Eps15, Protein AF-1p | AF1P
Primary ID P42566
Links - -
Type protein
Relations 8
Function Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK14up-regulates img/direct-activation.png phosphorylation EPS15 0.351
Publications: 1 Organism: Homo Sapiens
+ EGFRup-regulates img/direct-activation.png phosphorylation EPS15 0.746
Publications: 1 Organism: Homo Sapiens
+ PRKNup-regulates img/direct-activation.png ubiquitination EPS15 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ AP-2 complexup-regulates activity img/direct-activation.png binding EPS15 0.651
Publications: 1 Organism: Rattus Norvegicus
+ PRKNdown-regulates activity img/direct_inhibition.png ubiquitination EPS15 0.2
Publications: 1 Organism: Mus Musculus
+ EPS15up-regulates quantity by stabilization img/direct-activation.png binding AP-2/clathrin vescicle 0.677
Publications: 1
+ USP9Xdown-regulates activity img/direct_inhibition.png deubiquitination EPS15 0.277
Publications: 1 Organism: Homo Sapiens
+ EPS15down-regulates activity img/direct_inhibition.png binding EGFR 0.746
Publications: 1 Organism: Cricetulus Griseus