Summary

Name MRTFA
Full Name Myocardin-related transcription factor A
Synonyms Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein, Myocardin-related transcription factor A, MRTF-A | KIAA1438, MAL
Primary ID Q969V6
Links - -
Type protein
Relations 9
Function Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png KLF4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MRTFA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SRF 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle