Summary

Name MKL1
Full Name MKL/myocardin-like protein 1
Synonyms Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein, Myocardin-related transcription factor A, MRTF-A | KIAA1438, MAL
Primary ID Q969V6
Links - -
Type protein
Relations 7
Function Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MKL1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MKL1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SRF 0.39
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/indirect-activation.png MKL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png KLF4 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle