Summary

Name DTNBP1
Full Name Dysbindin
Synonyms Biogenesis of lysosome-related organelles complex 1 subunit 8, BLOC-1 subunit 8, Dysbindin-1, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein, HPS7 protein | BLOC1S8
Primary ID Q96EV8
Links - -
Type protein
Relations 4
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

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Relations

Regulator Mechanism target score ℹ
+ TRIM32down-regulates quantity img/direct_inhibition.png ubiquitination DTNBP1 0.559
Publications: 1 Organism: Chlorocebus Aethiops
+ DTNBP1up-regulates activity img/direct-activation.png binding WASF2 0.353
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus
+ DTNBP1up-regulates activity img/direct-activation.png binding ABI1 0.364
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus
+ DTNBP1form complex img/form-complex.png binding BLOC-1 0.8
Publications: 1 Organism: Homo Sapiens