Summary

Name TRIM32
Full Name E3 ubiquitin-protein ligase TRIM32
Synonyms 72 kDa Tat-interacting protein, RING-type E3 ubiquitin transferase TRIM32, Tripartite motif-containing protein 32, Zinc finger protein HT2A | HT2A
Primary ID Q13049
Links - -
Type protein
Relations 3
Function Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

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Relations

Regulator Mechanism target score ℹ
+ TRIM32down-regulates quantity img/direct_inhibition.png ubiquitination DTNBP1 0.559
Publications: 1 Organism: Chlorocebus Aethiops
+ TRIM32down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DBNDD1 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRIM32 0.2
Publications: 1 Organism: Homo Sapiens