3.0
Summary
| Name |  TRIM32View Modifications |
| Full Name | E3 ubiquitin-protein ligase TRIM32 |
| Synonyms | 72 kDa Tat-interacting protein, RING-type E3 ubiquitin transferase TRIM32, Tripartite motif-containing protein 32, Zinc finger protein HT2A | HT2A |
| Primary ID | Q13049 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHEK2 | up-regulates activity 
phosphorylation
|
TRIM32 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TRIM32 | down-regulates quantity 
ubiquitination
|
DTNBP1 | 0.552 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
TRIM32 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM32 | down-regulates quantity by destabilization
ubiquitination
|
DBNDD1 | 0.2 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |