| + |
ZNF503 | up-regulates activity 
|
PTK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261191 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25538248 |
Zpo2-overexpressing cells demonstrated high levels of pFAK compared with the control (Fig. 6A). Additionally, Western blot analysis indicated that, in response to Zpo2 expression, both EpH4.9 and PyMT cells increase FAK activity, as demonstrated by higher levels of pFAK staining (Fig. 6B). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TLE5 | down-regulates activity 
binding
|
ZNF503 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261192 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 19056829 |
these results show that Grg5 can specifically interact with the C-terminus of Nolz1. these data suggest that Nolz1 functions as a repressor molecule, and that Grg5 interactions with Nolz1 serve to modulate Nolz1 repressor function. Mechanistically, Grg5 is known to modulate Grg co-repressor activity, raising the possibility that classical Grg proteins mediate Nolz1-dependent transcriptional repression. GalNolz1ΔC22 showed increased repressor activity compared with GalNolz1, consistent with the ability of Grg5 to modulate Nolz1 repressor function. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
ZNF503 | down-regulates quantity by repression 
transcriptional regulation
|
GATA3 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261189 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28258171 |
Intriguingly, ZPO2/ZNF503 levels were higher in breast cancer samples with WT GATA3 than in those with mutated GATA3 (Fig. 1B). We found that Zpo2 down-regulated GATA3 levels, whereas shRNA-mediated Zpo2 knockdown enhanced GATA3 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF503 | down-regulates quantity by repression
transcriptional regulation
|
CDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261190 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25538248 |
We asked whether higher pFAK staining in cells expressing Zpo2 correlates with reduced E-cadherin levels. Immunostaining for E-cadherin in the EpH4.9 and PyMT stable cell lines indicated a decrease in overall E-cadherin staining in Zpo2-overexpressing cells compared with the control (Fig. 6C). Similarly, Western blot analysis indicated a reduction in E-cadherin expression in Zpo2-expressing cells compared with the control (Fig. 6D). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
ZNF503
- 
- 