| + |
PKA | up-regulates activity 
phosphorylation
|
GATA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276042 |
Ser308 |
IKPKRRLsAARRAGT |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 16109788 |
PKA-mediated phosphorylation increases the interaction between GATA3 and LRH-1 and the requirement for PKA in aromatase PII promoter stimulation involves at least three specific amino acid residues: GATA3 Ser308, GATA4 Ser261, and LRH-1 Ser469. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates quantity by destabilization 
phosphorylation
|
GATA3 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276634 |
Thr156 |
HLFTFPPtPPKDVSP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24820417 |
Phosphorylation of GATA3 Thr-156 was detected in mouse thymocytes, and cyclin-dependent kinase 2 (CDK2) was identified as a respondent for phosphorylation at Thr-156. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | up-regulates quantity by expression 
transcriptional regulation
|
IL4 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254500 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12876556 |
Initiation of transcription of the gene encoding IL-4 in naive T(H) cells is regulated by the T(H) 2-specific transcription factor GATA3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | down-regulates
binding
|
CEBPA |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250569 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17139329 |
Whereas others, such as GATA2/3 and SMAD3, physically interact with C/EBPα to inhibit its transcriptional activity on the Pparg2 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | down-regulates quantity by repression 
transcriptional regulation
|
FOXC2 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254089 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22120723 |
We show that the BRCA1-GATA3 interaction is important for the repression of genes associated with triple-negative and basal-like breast cancer (BLBCs) including FOXC1, and that GATA3 interacts with a C-terminal region of BRCA1. We demonstrate that this BRCA1-GATA3 repression complex is not a FOXC1-specific phenomenon as a number of other genes associated with BLBCs such as FOXC2, CXCL1 and p-cadherin were also repressed in a similar manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | up-regulates quantity by expression
transcriptional regulation
|
ERG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253920 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21536859 |
We further demonstrate that ERG expression in primary human T-ALL cells is mediated by the binding of other T-cell oncogenes SCL/TAL1, LMO2, and LYL1 in concert with ERG, FLI1, and GATA3 to the ERG +85 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates
|
GATA3 |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254299 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12947222 |
GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates activity
|
GATA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253527 |
|
|
|
|
| pmid |
sentence |
| 17139329 |
That GATA is a downstream effector of the hedgehog pathway. |
|
| Publications: |
1 |
| + |
SMAD1 | up-regulates quantity
transcriptional regulation
|
GATA3 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268938 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ARID5B | up-regulates quantity by expression
transcriptional regulation
|
GATA3 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
We also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW7 | down-regulates quantity by destabilization
ubiquitination
|
GATA3 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276635 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24820417 |
Fbw7 promotes degradation of GATA3 in a Thr-156-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | down-regulates
|
TBX21 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16386358 |
Conversely, T-bet is capable of inhibiting GATA-3 (Szabo et al., 2000). The mutual inhibition between GATA-3 and T-bet ensures that Th1 and Th2 cells express one or the other molecule (T-bet in Th1, and GATA-3 in Th2), but not both |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF503 | down-regulates quantity by repression
transcriptional regulation
|
GATA3 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261189 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28258171 |
Intriguingly, ZPO2/ZNF503 levels were higher in breast cancer samples with WT GATA3 than in those with mutated GATA3 (Fig. 1B). We found that Zpo2 down-regulated GATA3 levels, whereas shRNA-mediated Zpo2 knockdown enhanced GATA3 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | down-regulates
transcriptional regulation
|
PPARG |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210025 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15632071 |
Constitutive expression of both gata-2 and gata-3 suppressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-activated receptor gamma (ppargamma) promoter and suppression of its basal activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates quantity
transcriptional regulation
|
GATA3 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268943 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GATA3 | up-regulates
|
GATA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254297 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16386358 |
Experimental data indeed supports the existence of a positive circuit involvingGATA-3 that excludes IL-4 and STAT-6, specifically in mouse cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254300 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16386358 |
Experimental data indeed supports the existence of a positive circuit involvingGATA-3 that excludes IL-4 and STAT-6, specifically in mouse cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GATA3 | up-regulates activity
|
T-lymphocyte_diff |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259953 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22267605 |
Transcription factor GATA-3 is known to be vital for the development of T cells at multiple stages in the thymus and for Th2 differentiation in the peripheral organs |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GATA3 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132955 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15632071 |
Constitutive expression of both gata-2 and gata-3 suppressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-activated receptor gamma (ppargamma) promoter and suppression of its basal activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GATA3 | up-regulates quantity by expression
transcriptional regulation
|
GLS2 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268034 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 31577957 |
Thus, GATA3 contributes to the elevated expression of GLS2 in luminal-subtype breast cancers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX21 | down-regulates
|
GATA3 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254295 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16386358 |
Conversely, T-bet is capable of inhibiting GATA-3 (Szabo et al., 2000). The mutual inhibition between GATA-3 and T-bet ensures that Th1 and Th2 cells express one or the other molecule (T-bet in Th1, and GATA-3 in Th2), but not both |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | up-regulates quantity by expression
transcriptional regulation
|
CD8A |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8413295 |
Taken together, these results suggest that the human CD8 alpha gene is regulated by the interaction of multiple T-cell nuclear proteins with a transcriptional enhancer located in the last intron of the gene. Site-directed mutation of the Ets-1 and GATA-3 sites dramatically reduced enhancer activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASH2L | up-regulates
binding
|
GATA3 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205312 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 25258321 |
We identifiedgata3as the binding protein of ash2l. Ash2l was shown to potentiate the transcriptional activity ofgata3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA3 | down-regulates
binding
|
CEBPB |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132952 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15632071 |
In the present study, we demonstrate that both gata-2 and gata-3 form protein complexes with ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpbeta, members of a family of transcription factors that are integral to adipogenesis. []the interaction between gata and c/ebp factors is critical for the ability of gata to suppress adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GATA3 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78830 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11021798 |
Constitutive gata-2 and gata-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
GATA3
- 
- 