Relation Results

Summary

Name GATA3
Full Name Trans-acting T-cell-specific transcription factor GATA-3
Synonyms GATA-binding factor 3
Primary ID P23771
Links - -
Type protein
Relations 25
Pathways FAP: Adipogenic transcriptional cascade, FAP: SHH, T-Lymphocyte: IFN gamma, T-Lymphocyte: IL4 and its transcriptional regulation
Function Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Requ ...
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0.20.370.7510.4990.2520.4120.3380.3360.20.70.260.7510.3110.70.6470.2950.20.3390.3590.20.3540.3150.368PKAGATA3CDK2TBX21IL4ASH2LFBXW7GLS2FOXC2T-lymphocyte_diffZNF503CD8AAdipogenesisSTAT6SMAD1ERGARID5BCEBPBSMOPPARGSMAD5CEBPA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PKAup-regulates activity img/direct-activation.png phosphorylation GATA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276042 Ser308 IKPKRRLsAARRAGT Homo sapiens MCF-7 Cell
pmid sentence
 PKA-mediated phosphorylation increases the interaction between GATA3 and LRH-1 and the requirement for PKA in aromatase PII promoter stimulation involves at least three specific amino acid residues: GATA3 Ser308, GATA4 Ser261, and LRH-1 Ser469. 
Publications: 1 Organism: Homo Sapiens
+ CDK2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GATA3 0.37
Identifier Residue Sequence Organism Cell Line
SIGNOR-276634 Thr156 HLFTFPPtPPKDVSP Homo sapiens HeLa Cell
pmid sentence
Phosphorylation of GATA3 Thr-156 was detected in mouse thymocytes, and cyclin-dependent kinase 2 (CDK2) was identified as a respondent for phosphorylation at Thr-156.
Publications: 1 Organism: Homo Sapiens
+ GATA3down-regulates img/indirect_inhibition.png TBX21 0.751
Identifier Residue Sequence Organism Cell Line
SIGNOR-254296 Homo sapiens
pmid sentence
Conversely, T-bet is capable of inhibiting GATA-3 (Szabo et al., 2000). The mutual inhibition between GATA-3 and T-bet ensures that Th1 and Th2 cells express one or the other molecule (T-bet in Th1, and GATA-3 in Th2), but not both
Publications: 1 Organism: Homo Sapiens
+ GATA3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL4 0.499
Identifier Residue Sequence Organism Cell Line
SIGNOR-254500 Homo sapiens T-lymphocyte
pmid sentence
Initiation of transcription of the gene encoding IL-4 in naive T(H) cells is regulated by the T(H) 2-specific transcription factor GATA3
Publications: 1 Organism: Homo Sapiens
+ ASH2Lup-regulates img/direct-activation.png binding GATA3 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-205312 Homo sapiens Breast Cancer Cell
pmid sentence
We identifiedgata3as the binding protein of ash2l. Ash2l was shown to potentiate the transcriptional activity ofgata3.
Publications: 1 Organism: Homo Sapiens
+ FBXW7down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination GATA3 0.412
Identifier Residue Sequence Organism Cell Line
SIGNOR-276635 Homo sapiens HeLa Cell
pmid sentence
Fbw7 promotes degradation of GATA3 in a Thr-156-dependent manner. 
Publications: 1 Organism: Homo Sapiens
+ GATA3up-regulates quantity by expression img/direct-activation.png transcriptional regulation GLS2 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-268034 Homo sapiens Breast Cancer Cell Line
pmid sentence
Thus, GATA3 contributes to the elevated expression of GLS2 in luminal-subtype breast cancers.
Publications: 1 Organism: Homo Sapiens
+ GATA3down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXC2 0.336
Identifier Residue Sequence Organism Cell Line
SIGNOR-254089 Homo sapiens
pmid sentence
We show that the BRCA1-GATA3 interaction is important for the repression of genes associated with triple-negative and basal-like breast cancer (BLBCs) including FOXC1, and that GATA3 interacts with a C-terminal region of BRCA1. We demonstrate that this BRCA1-GATA3 repression complex is not a FOXC1-specific phenomenon as a number of other genes associated with BLBCs such as FOXC2, CXCL1 and p-cadherin were also repressed in a similar manner.
Publications: 1 Organism: Homo Sapiens
+ GATA3up-regulates img/direct-activation.png GATA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254297 Homo sapiens
pmid sentence
Experimental data indeed supports the existence of a positive circuit involvingGATA-3 that excludes IL-4 and STAT-6, specifically in mouse cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-254300 Homo sapiens
pmid sentence
Experimental data indeed supports the existence of a positive circuit involvingGATA-3 that excludes IL-4 and STAT-6, specifically in mouse cells
Publications: 2 Organism: Homo Sapiens
+ GATA3up-regulates activity img/indirect-activation.png T-lymphocyte_diff 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259953 Mus musculus
pmid sentence
Transcription factor GATA-3 is known to be vital for the development of T cells at multiple stages in the thymus and for Th2 differentiation in the peripheral organs
Publications: 1 Organism: Mus Musculus
+ ZNF503down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA3 0.26
Identifier Residue Sequence Organism Cell Line
SIGNOR-261189 Homo sapiens
pmid sentence
Intriguingly, ZPO2/ZNF503 levels were higher in breast cancer samples with WT GATA3 than in those with mutated GATA3 (Fig. 1B). We found that Zpo2 down-regulated GATA3 levels, whereas shRNA-mediated Zpo2 knockdown enhanced GATA3 expression
Publications: 1 Organism: Homo Sapiens
+ TBX21down-regulates img/indirect_inhibition.png GATA3 0.751
Identifier Residue Sequence Organism Cell Line
SIGNOR-254295 Homo sapiens
pmid sentence
Conversely, T-bet is capable of inhibiting GATA-3 (Szabo et al., 2000). The mutual inhibition between GATA-3 and T-bet ensures that Th1 and Th2 cells express one or the other molecule (T-bet in Th1, and GATA-3 in Th2), but not both
Publications: 1 Organism: Homo Sapiens
+ GATA3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD8A 0.311
Identifier Residue Sequence Organism Cell Line
SIGNOR-254079 Homo sapiens
pmid sentence
Taken together, these results suggest that the human CD8 alpha gene is regulated by the interaction of multiple T-cell nuclear proteins with a transcriptional enhancer located in the last intron of the gene. Site-directed mutation of the Ets-1 and GATA-3 sites dramatically reduced enhancer activity.
Publications: 1 Organism: Homo Sapiens
+ GATA3down-regulates img/indirect_inhibition.png Adipogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-78830 Mus musculus
pmid sentence
Constitutive gata-2 and gata-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage.
Publications: 1 Organism: Mus Musculus
+ STAT6up-regulates img/direct-activation.png GATA3 0.647
Identifier Residue Sequence Organism Cell Line
SIGNOR-254299 Homo sapiens
pmid sentence
GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6
Publications: 1 Organism: Homo Sapiens
+ SMAD1up-regulates quantity img/direct-activation.png transcriptional regulation GATA3 0.295
Identifier Residue Sequence Organism Cell Line
SIGNOR-268938 Mus musculus
pmid sentence
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation
Publications: 1 Organism: Mus Musculus
+ GATA3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253920 Homo sapiens
pmid sentence
We further demonstrate that ERG expression in primary human T-ALL cells is mediated by the binding of other T-cell oncogenes SCL/TAL1, LMO2, and LYL1 in concert with ERG, FLI1, and GATA3 to the ERG +85 enhancer.
Publications: 1 Organism: Homo Sapiens
+ ARID5Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation GATA3 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-256158 Homo sapiens
pmid sentence
We also observed that ARID5B regulates the expression of four major components of the TAL1 complex (namely, TAL1,GATA3, RUNX1, and MYB) in Jurkat cells. Knockdown of ARID5B resulted in reductions of the H3K27ac signals at those enhancer loci (Supplemental Fig. S6E–H) and down-regulation of all four factors at the mRNA (Fig. 6E) and protein levels (Fig. 6F).
Publications: 1 Organism: Homo Sapiens
+ GATA3down-regulates img/direct_inhibition.png binding CEBPB 0.359
Identifier Residue Sequence Organism Cell Line
SIGNOR-132952 Mus musculus
pmid sentence
In the present study, we demonstrate that both gata-2 and gata-3 form protein complexes with ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpbeta, members of a family of transcription factors that are integral to adipogenesis. []the interaction between gata and c/ebp factors is critical for the ability of gata to suppress adipocyte differentiation.
Publications: 1 Organism: Mus Musculus
+ SMOup-regulates activity img/direct-activation.png GATA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253527
pmid sentence
That GATA is a downstream effector of the hedgehog pathway.
Publications: 1
+ GATA3down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.354
Identifier Residue Sequence Organism Cell Line
SIGNOR-210025 Homo sapiens
pmid sentence
Constitutive expression of both gata-2 and gata-3 suppressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-activated receptor gamma (ppargamma) promoter and suppression of its basal activity
Publications: 1 Organism: Homo Sapiens
+ GATA3down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.354
Identifier Residue Sequence Organism Cell Line
SIGNOR-132955 Mus musculus
pmid sentence
Constitutive expression of both gata-2 and gata-3 suppressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-activated receptor gamma (ppargamma) promoter and suppression of its basal activity
Publications: 1 Organism: Mus Musculus
+ SMAD5up-regulates quantity img/direct-activation.png transcriptional regulation GATA3 0.315
Identifier Residue Sequence Organism Cell Line
SIGNOR-268943 Mus musculus
pmid sentence
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation
Publications: 1 Organism: Mus Musculus
+ GATA3down-regulates img/direct_inhibition.png binding CEBPA 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-250569 Homo sapiens
pmid sentence
Whereas others, such as GATA2/3 and SMAD3, physically interact with C/EBPα to inhibit its transcriptional activity on the Pparg2 promoter.
Publications: 1 Organism: Homo Sapiens
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