| + |
MAML3 | up-regulates 
binding
|
NOTCH |
0.88 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We report here the cloning and characterization of two new genes, maml2 and maml3, that also function as transcriptional coactivators for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML3 | up-regulates
binding
|
NOTCH4 |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
Whereas maml1 and maml2 functioned efficiently as coactivators with each of the notch receptors to transactivate a notch target hes1 promoter construct, maml3 functioned more efficiently with icn4 than with other forms of icn. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBPJ | up-regulates
binding
|
MAML3 |
0.873 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21873209 |
When bound to the active intracellular domain of notch (nicd), rbpj recruits a coactivator complex, including a mastermind homologue (maml1-3 in mammals), and drives a complex transcriptional program with pervasive phenotypic effects. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates
binding
|
MAML3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254346 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
Genetic ablation or activation of the pathway reveals that Notch signalling promotes differentiation of the hair follicle, sebaceous gland and interfollicular epidermal lineages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML3 | up-regulates
binding
|
NOTCH2 |
0.747 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94097 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We report here the cloning and characterization of two new genes, maml2 and maml3, that also function as transcriptional coactivators for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH4 | up-regulates
binding
|
MAML3 |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94109 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
Moreover, as determined by using coimmunoprecipitation assays, each maml protein was found to be capable of forming a multiprotein complex with the intracellular domain of each notch receptor (icn1 to -4) and csl in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML3 | up-regulates
binding
|
NOTCH3 |
0.878 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We report here the cloning and characterization of two new genes, maml2 and maml3, that also function as transcriptional coactivators for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAML3
- 
- 