+ |
PRKD1 | down-regulates
phosphorylation
|
DLC1 |
0.386 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-169994 |
Ser1244 |
NTLKRENsSPRVMQR |
Homo sapiens |
|
pmid |
sentence |
21087603 |
The tumor suppressor protein dlc1 is regulated by pkd-mediated gap domain phosphorylation.Our results thus show that pkd-mediated phosphorylation of dlc1 on serine 807 negatively regulates dlc1 cellular function. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AKT1 |
phosphorylation
|
DLC1 |
0.514 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252550 |
Ser766 |
VTRTRSLsACNKRVG |
Rattus norvegicus |
|
pmid |
sentence |
16338927 |
We have demonstrated that Ser-322 is phosphorylated upon insulin stimulation of intact cells and that this site is directly phosphorylated in vitro by PKB and ribosomal S6 kinase, members of the AGC (protein kinases A, G, and C) family of insulin-stimulated protein kinases |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |
+ |
AKT |
phosphorylation
|
DLC1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-247997 |
Ser766 |
VTRTRSLsACNKRVG |
Rattus norvegicus |
Adipocyte |
pmid |
sentence |
16338927 |
We have demonstrated that Ser-322 is phosphorylated upon insulin stimulation of intact cells and that this site is directly phosphorylated in vitro by PKB and ribosomal S6 kinase, members of the AGC (protein kinases A, G, and C) family of insulin-stimulated protein kinases |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |
+ |
DLC1 | down-regulates activity
binding
|
MYH9 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269283 |
|
|
Homo sapiens |
OC-3 Cell |
pmid |
sentence |
26977077 |
Our study has shown that Dlc1 interacts with non-muscle myosin heavy chain II-A (Myh9), plectin and spectrin proteins in different multiprotein complexes. Overexpression of Dlc1 led to increased phosphorylation of Myh9 protein and activation of Rac1 GTPase. Dlc1 interacts with phosphorylated Myh9 (Ser-1943). This association of Dlc1 with S1943 phosphorylated Myh9, suggests that Dlc1 may be involved in reduced Myh9 filament stability. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |