Relation Results

Summary

Name TP53RK
Full Name EKC/KEOPS complex subunit TP53RK
Synonyms Atypical serine/threonine protein kinase TP53RK, EKC/KEOPS complex subunit TP53RK, 3.6.-.-, Nori-2, p53-related protein kinase | C20orf64, PRPK
Primary ID Q96S44
Links - -
Type protein
Relations 4
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that ...
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Type: Score: Layout: SPV 
0.7540.20.30.0TP53RKTP53AKTAKT1PBK

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ TP53RKup-regulates img/direct-activation.png phosphorylation TP53 0.754
Identifier Residue Sequence Organism Cell Line
SIGNOR-157471 Ser15 PSVEPPLsQETFSDL Homo sapiens
pmid sentence
The intrinsic transcriptional activity of p53 was up-regulated by a transient transfection of prpk to cos-7 cells. Prpk was shown to bind to p53 and to phosphorylate p53 at ser-15.
Publications: 1 Organism: Homo Sapiens
+ AKTup-regulates img/direct-activation.png phosphorylation TP53RK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-157467 Ser250 RLRGRKRsMVG Homo sapiens
pmid sentence
Here we show that such an activation of prpk is mediated by another kinase, akt/pkb, which phosphorylates prpk at ser250.
Publications: 1 Organism: Homo Sapiens
+ AKT1up-regulates img/direct-activation.png phosphorylation TP53RK 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-252503 Ser250 RLRGRKRsMVG Homo sapiens
pmid sentence
Here we show that such an activation of prpk is mediated by another kinase, akt/pkb, which phosphorylates prpk at ser250.
Publications: 1 Organism: Homo Sapiens
+ PBKup-regulates activity img/direct-activation.png phosphorylation TP53RK
Identifier Residue Sequence Organism Cell Line
SIGNOR-278236 Ser250 RLRGRKRsMVG Homo sapiens
pmid sentence
In this study, we provide evidence showing that TOPK promotes metastasis of colorectal carcinoma, which is mediated through its phosphorylation of PRPK at Ser250.|Therefore, we conclude that TOPK directly promotes metastasis of colorectal cancer by modulating PRPK.
Publications: 1 Organism: Homo Sapiens
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